Evidence map›Paper›PMID 34384038›Full record

ArticleVirulence2021

Oral administration of

Wenwen Zhu, Jia Wang, Na Zhao, Rui Zheng, Dalu Wang, Weiwei Liu, Beixing Liu

Abstract read
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Nutrients · 2026
    Article
  3. The role ofFrontiers in immunology · 2026
    Review
  4. Article
  5. Review
  6. Microbiome modifications by steroids during viral exacerbation of asthma and in healthy mice.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Host tracheal and intestinal microbiomes inhibitbioRxiv : the preprint server for biology · 2023
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Annals of translational medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenwen ZhuDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China.
Jia WangDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China.
Na ZhaoDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China.
Rui ZhengDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China.
Dalu WangDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China.
Weiwei LiuDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China.
Beixing LiuDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in the intestinal microbiota indirectly impact the health of mucosa distal to the intestine, particularly the respiratory tract. However, the effects of intestinal microbiota dysbiosis on the regulation of respiratory syncytial virus (RSV) infection are not clear. In this study, we examined the effects of altering the intestinal microbiota on the pulmonary immune response against RSV infection. BALB/c mice were treated with streptomycin before infection with RSV to study the altered immune response. The ingestion of streptomycin led to a marked alteration in the intestinal microbiota with a reduced abundance of

Indexed as

Clostridium butyricumGastrointestinal MicrobiomePneumonia, ViralRespiratory Syncytial Virus InfectionsAdministration, OralAnimalsDysbiosisInflammationInterferon-gammaInterleukin-17Interleukin-5MacrophagesMiceMice, Inbred BALB CRespiratory Syncytial Virus, HumanStreptomycinInterferon-gammaInterleukin-17Interleukin-5StreptomycinbutyrateClostridium butyricumGastrointestinal microbiotaimmune responsemacrophagesRSV

Identifiers

PMID34384038
PMCPMC8366546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.