Evidence map›Paper›PMID 34384032›Full record

ArticleEpigenetics

Early-pregnancy maternal body mass index is associated with common DNA methylation markers in cord blood and placenta: a paired-tissue epigenome-wide association study.

Nidhi Ghildayal, Ruby Fore, Sharon M Lutz, Andres Cardenas, Patrice Perron, Luigi Bouchard, Marie-France Hivert

Open access · greenAbstract read
In one paragraph

Article in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nidhi GhildayalDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, United States of America.ORCID 0000-0002-7792-3431
Ruby ForeDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, United States of America.
Sharon M LutzDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, United States of America.
Andres CardenasDivision of Environmental Health Sciences, School of Public Health & Center for Computational Biology, University of California, Berkeley, CA, United States of America.ORCID 0000-0003-2284-3298
Patrice PerronDepartment of Medicine, Faculté De Médecine Et Des Sciences De La Santé, Université De Sherbrooke, Sherbrooke, Canada.
Luigi BouchardCentre De Recherche Du Centre Hospitalier Universitaire De Sherbrooke, Sherbrooke, Canada.
Marie-France HivertDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, United States of America.
Harvard University · USUniversité de Sherbrooke · CAUniversity of California, Berkeley · US

Funding

Impact of insulin-like growth factors and binding proteins on gestational diabetes and fetal growthR01HD094150 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Camille Elise Powe · 2018 to 2026
$4.2M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
Common Genetic Pathways Underlying CVD and COPDK01HL125858 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LUTZ, SHARON MARIE · 2015 to 2019
$721k
CIHR 115071CIHR MOP 115071NHLBI NIH HHS K01 HL125858NICHD NIH HHS R01 HD094150NIEHS NIH HHS R01 ES031259
6 · The paper itself

Abstract

Women entering pregnancy with elevated body mass index (BMI) face greater risk of adverse outcomes during pregnancy, delivery, and for their offspring later in life, potentially via epigenetics. If epigenetic programming occurs early during

Indexed as

DNA MethylationEpigenomeBody Mass IndexEpigenesis, GeneticFemaleFetal BloodHumansHypothalamo-Hypophyseal SystemInfantInfant, NewbornPituitary-Adrenal SystemPlacentaPregnancyProspective Studiesbody mass indexcord blooddevelopmental programmingDNA methylationepigenome-wide association studyplacentapregnancy

Identifiers

PMID34384032
PMCPMC9336499
OpenAlexW3190250502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.