Evidence map›Paper›PMID 34383995›Full record

ReviewChembiochem : a European journal of chemical biology2022

Indole-3-Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target.

Nikolas Esposito, David W Konas, Nina M Goodey

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nikolas EspositoDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ, 07043, USA.
David W KonasDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ, 07043, USA.
Nina M GoodeyDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ, 07043, USA.
Montclair State University · US

Funding

Investigation of Substrate Specificity, Mechanism, and Inhibition of IGPSR15GM126467 · NIGMS · MONTCLAIR STATE UNIVERSITY · PI GOODEY, NINA M · 2018 to 2018
$302k
National Science Foundation DUE-1458499NIGMS NIH HHS R15 GM126467
6 · The paper itself

Abstract

Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis, affects millions of people worldwide. Several TB drugs have lost efficacy due to emerging drug resistance and new anti-TB targets are needed. Recent research suggests that indole-3-glycerol phosphate synthase (IGPS) in M. tuberculosis (MtIGPS) could be such a target. IGPS is a (β/α)

Indexed as

Drug Delivery SystemsAmino Acid SequenceAntitubercular AgentsBiocatalysisCD4-Positive T-LymphocytesHumansIndole-3-Glycerol-Phosphate SynthaseMycobacterium tuberculosisSequence Homology, Amino AcidAntitubercular AgentsIndole-3-Glycerol-Phosphate Synthasedrug targetindole-3-glycerol phosphate synthase (IGPS)M. tuberculosisprotein engineering scaffoldtryptophan biosynthetic pathway

Identifiers

PMID34383995
PMCPMC9041893
OpenAlexW3187281974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.