Evidence map›Paper›PMID 34383984›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Zfhx3 modulates retinal sensitivity and circadian responses to light.

Steven Hughes, Jessica K Edwards, Ashleigh G Wilcox, Carina A Pothecary, Alun R Barnard, Russell Joynson, Greg Joynson, Mark W Hankins, Stuart N Peirson, Gareth Banks and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  7. Zfhx3 modulates retinal sensitivity and circadian responses to light.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Steven HughesNuffield Department of Clinical Neurosciences, Sir William Dunn School of Pathology, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Jessica K EdwardsMRC Harwell Institute, Oxfordshire, UK.
Ashleigh G WilcoxMRC Harwell Institute, Oxfordshire, UK.
Carina A PothecaryNuffield Department of Clinical Neurosciences, Sir William Dunn School of Pathology, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Alun R BarnardNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Russell JoynsonMRC Harwell Institute, Oxfordshire, UK.
Greg JoynsonMRC Harwell Institute, Oxfordshire, UK.
Mark W HankinsNuffield Department of Clinical Neurosciences, Sir William Dunn School of Pathology, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Stuart N PeirsonNuffield Department of Clinical Neurosciences, Sir William Dunn School of Pathology, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-3653-834X
Gareth BanksMRC Harwell Institute, Oxfordshire, UK.
Patrick M NolanMRC Harwell Institute, Oxfordshire, UK.ORCID https://orcid.org/0000-0001-5550-0334
Mary Lyon Centre at MRC Harwell · GBUniversity of Oxford · GB

Funding

BBSRC BB/I021086/1Medical Research Council MC_U142684173Medical Research Council MR/S026266/1MRC MC_U142684173Wellcome TrustWellcome Trust 098461/Z/12/Z
6 · The paper itself

Abstract

Mutations in transcription factors often exhibit pleiotropic effects related to their complex expression patterns and multiple regulatory targets. One such mutation in the zinc finger homeobox 3 (ZFHX3) transcription factor, short circuit (Sci, Zfhx3

Indexed as

Amacrine CellsAnimalsCircadian RhythmHomeodomain ProteinsLightLocomotionMaleMiceMice, Inbred C57BLPhotic StimulationRetinaRetinal Ganglion CellsVision, OcularHomeodomain ProteinsZfhx3 protein, mouseamacrine celllight sensitivitymutationpleiotropypupillary reflex

Identifiers

PMID34383984
PMCPMC9292409
OpenAlexW3190857481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.