ArticlePloS one2021
Differential responses of salivary cortisol, amylase, and chromogranin A to academic stress.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Open-label placebo effects on psychological distress and hair cortisol in a randomized controlled trial - the moderating role of the five-factor personality traits.Comprehensive psychoneuroendocrinology · 2026Article
- Chromogranin A and S100A12 protein measurement in hair of pigs: assay validation, changes across different production stages and comparison with other hair biomarkers.Veterinary research communications · 2026Article
- Salivary responses to an experimental activation of the HPA axis in pigs: Effects of ACTH on analytes related to stress, immune system, inflammation, redox status and metabolism.Veterinary and animal science · 2026Article
- Stability of salivary cortisol, alpha-amylase, and chromogranin A after long-term storage.Scientific reports · 2026Article
- Salivary Stress Biomarkers (Chromogranin A and Secretory IgA): Associations with Anxiety and Depressive Symptoms in Healthcare Professionals.Nursing reports (Pavia, Italy) · 2025Article
- Examination of the Communication Environment When Applying Removable Dentures as Wearable Devices.Cureus · 2025Article
- Linking Premenstrual Syndrome With Salivary Alpha-Amylase Levels and Stress Levels: A Cross-Sectional Study.Journal of family & reproductive health · 2025Article
- Salivary Biosensing Opportunities for Predicting Cognitive and Physical Human Performance.Biosensors · 2025Article
- Salivary Biomarkers as a Predictive Factor in Anxiety, Depression, and Stress.Current issues in molecular biology · 2025Review
- Saliva as a Diagnostic Tool for Systemic Diseases-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- They're Only Human! Tension and Stress Predict Performance of Softball Umpires in National Championships.Sports (Basel, Switzerland) · 2025Article
- Rapid optical determination of salivary cortisol responses in individuals undergoing physiological and psychological stress.Scientific reports · 2024Article
- The Use of Coffee Aroma for Stress Reduction in Postgraduate Dental Students.International dental journal · 2024Article
- Feeling the Stress: Salivary Cortisol Responses of Softball Umpires during National Championships.Sports (Basel, Switzerland) · 2024Article
- The effect of live-performed music therapy with physical contact in preterm infants on parental perceived stress and salivary cortisol levels.Frontiers in psychology · 2024Article
- Psychophysiological wellbeing in a class of dental students attending dental school: anxiety, burnout, post work executive performance and a 24 hours physiological investigation during a working day.Frontiers in psychology · 2024Article
- Anxiety in a regular day of work: A 24 hour psychophysiological investigation in young dentists with gender comparison.Frontiers in psychology · 2023Article
- Baseline states of mind differentially affected diurnal salivary stress biomarkers: A preliminary study.Heliyon · 2022Article
- Associations between chronic work stress and plasma chromogranin A/catestatin among healthy workers.Journal of occupational health · 2022Article
- Salivary mental stress biomarkers in COVID-19 patients.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salivary biomarkers have been widely used to help diagnose stress, anxiety, and/or depression. This study aimed to compare the responses of three commonly investigated salivary stress biomarkers that represent the hypothalamic-pituitary-adrenal activity (cortisol; sCort) and the sympathetic activity (alpha-amylase; sAA and chromogranin A; sCgA), using academic oral presentation as a model of stress. Twenty postgraduate dental students attended the seminar class as presenter and audience. The presenters' performances were evaluated by the instructors suggesting more stress than the audience. The saliva was collected two times: before attending class and after an academic presentation (for presenters) or during the class (for audience). The pulse rates (PR) were also recorded. The results showed that the levels of all three biomarkers, as well as PR, were significantly higher in the presenter group compared with the audience group; however, the changes were most prominent with sCort and sAA (99.56 ± 12.76% for sCort, 93.48 ± 41.29% for sAA, 16.86 ± 6.42% for sCgA, and 15.06 ± 3.41% for PR). When compared between pre-post presentation, the levels of sCgA were not different, while those of sCort and sAA were significantly increased. These results suggest more sensitive reactivity to academic stress of sCort and sAA compared with sCgA and that the response of sCgA did not necessarily follow sAA pattern even though both are claimed to reflect the sympathetic activity. More studies are needed to elucidate the roles of sCgA in stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.