Evidence map›Paper›PMID 34383248›Full record

SynthesisAging clinical and experimental research2022

The effect of combined cognitive intervention and physical exercise on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials.

Qiuyan Meng, Huiru Yin, Shuo Wang, Binghan Shang, Xiangfei Meng, Mingli Yan, Guichen Li, Jianfeng Chu, Li Chen

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 15 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 15 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qiuyan Meng *School of Nursing, Jilin University, No. 965 Xinjiang Road, Changchun, 130021, China.
Huiru Yin *School of Nursing, Jilin University, No. 965 Xinjiang Road, Changchun, 130021, China.
Shuo WangSchool of Nursing, Jilin University, No. 965 Xinjiang Road, Changchun, 130021, China.
Binghan ShangHenan Provincial People's Hospital, Zhengzhou, China.
Xiangfei MengSchool of Nursing, Jilin University, No. 965 Xinjiang Road, Changchun, 130021, China.
Mingli YanSchool of Nursing, Jilin University, No. 965 Xinjiang Road, Changchun, 130021, China.
Guichen LiSchool of Nursing, Jilin University, No. 965 Xinjiang Road, Changchun, 130021, China.
Jianfeng ChuSchool of Computer Science and Technology, Jilin University, No. 2699 Qianjin Street, Changchun, 130012, China. chujf@jlu.edu.cn.
Li ChenSchool of Nursing, Jilin University, No. 965 Xinjiang Road, Changchun, 130021, China. chen_care@126.com.ORCID http://orcid.org/0000-0001-9556-9053
Jilin University · CNHenan Provincial People's Hospital · CN

Funding

the Education Department of Jilin Province, China 2015J505the Health and Family Planning Committee of Jilin Province, China 2020J036
6 · The paper itself

Abstract

backgroundThe state of mild cognitive impairment (MCI) provides an optimal window for preventing progression to dementia. Combined cognitive intervention and physical exercise may yield additive and synergistic effects on cognition in older adults with MCI.

objectivesThe purpose of this study was to assess the efficacy of a combined intervention to improve cognition in older adults with MCI by comparing a control group that underwent only cognitive intervention, a control group that underwent only physical exercise, and a control group that did not undergo cognitive intervention or physical exercise.

designMeta-analysis of randomized controlled trials (RCTs). DATA SOURCES: The online databases of PubMed, Web of Science, Embase, the Cochrane Library, PsycINFO, and CINAHL were systematically searched. REVIEW

methodsThe outcomes were global cognition, memory, and executive function/attention. A sensitivity analysis was conducted when the I

resultsA total of 16 studies were included. The results showed that the combined intervention had positive effects on global cognition compared to the effects of the other control group [SMD = 0.27, 95% CI (0.09, 0.44), p = 0.003]. Regarding memory, the combined intervention had positive effects compared to the effects observed in the single physical exercise group [SMD = 0.25, 95% CI (0.07, 0.44), p = 0.006] and the other control group [SMD = 0.29, 95% CI (0.12, 0.47), p = 0.001]. For executive function/attention, the combined intervention had also positive effects compared to the effects of the single cognitive intervention group [SMD = 0.28, 95% CI (0.09, 0.47), p = 0.004], the single physical exercise group [SMD = 0.32, 95% CI (0.16, 0.49), p = 0.0002], and the other control group [SMD = 0.23, 95% CI (0.05, 0.41), p = 0.01].

conclusionsThe combined intervention resulted in cognitive benefits in older adults with MCI and exhibited limited superiority over the single cognitive intervention and the single physical exercise on cognitive subdomains.

Indexed as

Cognitive DysfunctionAgedCognitionExecutive FunctionExerciseHumansRandomized Controlled Trials as TopicCognitionCognitive dysfunctionCognitive interventionExerciseOlder adults

Identifiers

PMID34383248
OpenAlexW3191714130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.