Evidence map›Paper›PMID 34382934›Full record

ArticleeLife2021

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.

Joanna L Gillis, Josephine A Hinneh, Natalie K Ryan, Swati Irani, Max Moldovan, Lake-Ee Quek, Raj K Shrestha, Adrienne R Hanson, Jianling Xie, Andrew J Hoy and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  8. Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Metabolic adaptations in prostate cancer.British journal of cancer · 2024
    Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Joanna L GillisAdelaide Medical School, University of Adelaide, Adelaide, Australia.
Josephine A HinnehAdelaide Medical School, University of Adelaide, Adelaide, Australia.
Natalie K RyanAdelaide Medical School, University of Adelaide, Adelaide, Australia.
Swati IraniAdelaide Medical School, University of Adelaide, Adelaide, Australia.
Max MoldovanSouth Australian Health and Medical Research Institute, Adelaide, Australia.
Lake-Ee QuekSchool of Mathematics and Statistics, Charles Perkins Centre, Faculty of Science, The University of Sydney, Camperdown, Australia.
Raj K ShresthaAdelaide Medical School, University of Adelaide, Adelaide, Australia.
Adrienne R HansonFlinders Health and Medical Research Institute, Flinders University, College of Medicine and Public Health, Bedford Park, Australia.
Jianling XieFlinders Health and Medical Research Institute, Flinders University, College of Medicine and Public Health, Bedford Park, Australia.
Andrew J HoySchool of Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.ORCID 0000-0003-3922-1137
Jeff HolstSchool of Medical Sciences and Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.ORCID 0000-0002-0377-9318
Margaret M CenteneraAdelaide Medical School, University of Adelaide, Adelaide, Australia.
Ian G MillsCentre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland, United Kingdom.
David J LynnSouth Australian Health and Medical Research Institute, Adelaide, Australia.
Luke A SelthAdelaide Medical School, University of Adelaide, Adelaide, Australia.ORCID 0000-0002-4686-1418
Lisa M ButlerAdelaide Medical School, University of Adelaide, Adelaide, Australia.ORCID 0000-0003-2698-3220
South Australian Health and Medical Research Institute · AUFlinders University · AUThe University of Sydney · AUQueen's University Belfast · GBUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are hallmarks of prostate cancer. This study provides insight into both hallmarks by uncovering a novel link between AR and the pentose phosphate pathway (PPP). Specifically, we identify 6-phosphogluoconate dehydrogenase (

Indexed as

Acetyl-CoA CarboxylaseAMP-Activated Protein KinasesCell LineEmodinFeedbackGene Expression Regulation, NeoplasticGene Knockdown TechniquesGlyceraldehyde-3-Phosphate DehydrogenasesHumansMaleMechanistic Target of Rapamycin Complex 1Pentose Phosphate PathwayProstatic NeoplasmsReceptors, AndrogenSignal TransductionSterol Regulatory Element Binding Protein 1ACACA protein, humanAcetyl-CoA CarboxylaseAMP-Activated Protein KinasesAR protein, humanEmodinGlyceraldehyde-3-Phosphate DehydrogenasesMechanistic Target of Rapamycin Complex 1physcioneReceptors, AndrogenSREBF1 protein, humanSterol Regulatory Element Binding Protein 1androgen receptorcancer biologyhumanpentose phosphate pathwayprostate cancer

Identifiers

PMID34382934
PMCPMC8416027
OpenAlexW3193125454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.