Evidence map›Paper›PMID 34382933›Full record

ArticleeLife2021

Loss of

Isao Masuda, Jae-Yeon Hwang, Thomas Christian, Sunita Maharjan, Fuad Mohammad, Howard Gamper, Allen R Buskirk, Ya-Ming Hou

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 37 citations in OpenAlex.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Nicotinamide-Based Covalent Inhibitors of tRNA (mACS medicinal chemistry letters · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Mechanistic insights intobioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Interrogating the regulatory epigenome of cellular senescence.Cellular and molecular life sciences : CMLS · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  20. Modifications in the T arm of tRNA globally determine tRNA maturation, function, and cellular fitness.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Isao Masuda *Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, United States.ORCID 0000-0001-9385-4424
Jae-Yeon Hwang *Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.
Thomas Christian *Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, United States.
Sunita MaharjanDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, United States.
Fuad MohammadDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.
Howard GamperDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, United States.
Allen R BuskirkDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0003-2720-6896
Ya-Ming HouDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, United States.ORCID 0000-0001-6546-2597
Thomas Jefferson University · USJohns Hopkins University · US

Funding

tRNA in codon usageR35GM134931 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2020 to 2025
$5.4M
TrmD-targeting actinobacterial natural products as next generation antibioticsR01AI164490 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING, SHEN, BEN · 2021 to 2025
$4.2M
Discovery of Gram-negative permeable chemical probes for tRNA methylationR01AI139202 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2019 to 2022
$2.4M
The Mechanism of Pausing and Restarting Translation in BacteriaR01GM110113 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BUSKIRK, ALLEN ROWDON · 2014 to 2017
$1.2M
NIAID NIH HHS R01 AI139202NIAID NIH HHS R01 AI164490NIGMS NIH HHS R01 GM110113NIGMS NIH HHS R35 GM134931
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Frameshifting, RibosomalGene ExpressionAmino AcidsEscherichia coliMethylationProtein BiosynthesisRNA, TransferSubstrate SpecificityAmino AcidsRNA, TransferE. coliinfectious diseasem1G37-tRNAmicrobiologyribosome pausingribosome proflingstringent responseTrmD

Identifiers

PMID34382933
PMCPMC8384417
OpenAlexW3193044316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.