ArticleMagnetic resonance in medicine2022
Role of chemical exchange on the relayed nuclear Overhauser enhancement signal in saturation transfer MRI.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
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- Enhancing amide proton transfer imaging in ischemic stroke using a machine learning approach with partially synthetic data.NMR in biomedicine · 2025Article
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- In vivo imaging of glycogen in human muscle.Nature communications · 2024Article
- Amide proton transfer MRI at 9.4 T for differentiating tissue acidosis in a rodent model of ischemic stroke.Magnetic resonance in medicine · 2024Article
- Whole-cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack-of-spirals gradient echo acquisition.Magnetic resonance in medicine · 2024Article
- A rapid method for phosphocreatine-weighted imaging in muscle using double saturation power-chemical exchange saturation transfer.NMR in biomedicine · 2024Article
- Adjustment of rotation and saturation effects (AROSE) for CEST imaging.Magnetic resonance in medicine · 2024Article
- Simultaneous creatine and phosphocreatine mapping of skeletal muscle by CEST MRI at 3T.Magnetic resonance in medicine · 2024Article
- CEST and nuclear Overhauser enhancement imaging with deep learning-extrapolated semisolid magnetization transfer reference: Scan-rescan reproducibility and reliability studies.Magnetic resonance in medicine · 2024Article
- Investigation of relayed nuclear Overhauser enhancement effect at -1.6 ppm in an ischemic stroke model.Quantitative imaging in medicine and surgery · 2023Article
- Numerical simulation-based assessment of pH-sensitive chemical exchange saturation transfer MRI quantification accuracy across field strengths.NMR in biomedicine · 2023Article
- Validation of the presence of fast exchanging amine CEST effect at low saturation powers and its influence on the quantification of APT.Magnetic resonance in medicine · 2023Article
- Assignment of molecular origins of NOE signal at -3.5 ppm in the brain.Magnetic resonance in medicine · 2023Article
- Chemical exchange saturation transfer imaging of creatine, phosphocreatine, and protein arginine residue in tissues.NMR in biomedicine · 2023Review
- NOE-weighted imaging in tumors using low-duty-cycle 2π-CEST.Magnetic resonance in medicine · 2023Article
- Average saturation efficiency filter ASEF-CEST MRI of stroke rodents.Magnetic resonance in medicine · 2023Article
- Guanidinium and amide CEST mapping of human brain by high spectral resolution CEST at 3 T.Magnetic resonance in medicine · 2023Article
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2 authors at 2 institutions in 2 countries.
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Abstract
purposeThe pH sensitivity of chemical exchange-relayed nuclear Overhauser enhancement (rNOE) signal in a saturation transfer experiment is not fully understood and needs further investigation.
methodsA three-pool-exchange model was simulated assuming that the magnetization transfer between an NOE pool and water is relayed by a chemical exchange (CE) pool. The saturation transfer signals from bovine serum albumin (BSA) and egg white albumin (EWA) phantoms were measured with different pH or different D
resultsSimulation results showed that the rNOE signal is independent of the Larmor frequency of the CE pool, indicating any CE pool can effectively relay NOE magnetization. The rNOE signal is sensitive to a change of the CE pool size and/or exchange rate only if the CE becomes a rate-limiting step in the relay process. The rNOE signal from BSA phantoms showed larger pH-dependence at -3.0 ppm than those at -1.9 and -4.0 ppm. However, rNOE signals from aliphatic protons have much weaker pH-dependence than the CEST signal, suggesting that CE is unlikely the rate-limiting step and the rNOE signals in BSA are mainly relayed by fast exchanging protons. The existence of aromatic NOE was confirmed by proton spectroscopy.
conclusionThe pH-sensitivity of the rNOE signal is determined by whether the CE process is a rate-limiting step in the relay. The rNOE signal has much weaker pH-sensitivity than the CEST signal in BSA proteins, which can explain the weak pH sensitivity of rNOE in vivo.
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