Evidence map›Paper›PMID 34382582›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2021

Effect of intrathecal administration of exogenous noggin on neuropathic pain.

Wenjuan Zhang, Changqing Liu, Xin Wang, Junmei Xu, Lin Yang

Open access · greenAbstract read
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Noggin alleviates neuropathic pain by regulating microglial polarization and remodeling iron homeostasis via a STAT3-dependent pathway.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wenjuan ZhangDepartment of Laboratory, Second Xiangya Hospital, Central South University, Changsha 410011.
Changqing LiuDepartment of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Xin WangDepartment of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Junmei XuDepartment of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Lin YangDepartment of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

the Natural Science Foundation of Hunan Province, China 2020JJ5837
6 · The paper itself

Abstract

objectivesTo explore the effect of intrathecal administration of exogenous noggin (NOG) on the pain behavior in the neuropathic pain (NP) rats through L

methodsA total of 40 adult male Sprague Dawley (SD) rats were randomly divided into 3 groups: a control group (

resultsCompared with the control group, the PWT in the SNL group was markedly decreased at each time point, together with the increase in GFAP, IL-6 and the ratio of p-STAT3/STAT3 (all

conclusionsThe intrathecal administration of NOG may alleviate NP in the SNL rats through inhibiting astrocyte activation and down-regulating the STAT3 signal pathway.

Indexed as

NeuralgiaAnimalsHyperalgesiaInjections, SpinalMaleRatsRats, Sprague-DawleySpinal CordSpinal Cord Dorsal HornSpinal Nervesastrocyte activationbone morphogenetic proteinsneuropathic painnogginsignal transducer and activator of transcription 3

Identifiers

PMID34382582
PMCPMC10930133
OpenAlexW3189306269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.