Evidence map›Paper›PMID 34382443›Full record

ArticleEuropean journal of ophthalmology2022

Effect of light backscattering from anterior segment structures on automated flare meter measurements.

Murat Hasanreisoglu, Cem Kesim, Duygu Yalinbas, Mervenur Yilmaz, Nur Sena Uzunay, Zeynep Aktas, Muhammad Sohail Halim, Yasir J Sepah, Quan Dong Nguyen, Afsun Sahin

Open access · greenAbstract read
In one paragraph

Article in European journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Laser flare photometry in uveitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Murat HasanreisogluDepartment of Ophthalmology, Koç University School of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-9885-5653
Cem KesimDepartment of Ophthalmology, Koç University School of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-6747-1534
Duygu YalinbasDepartment of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey.
Mervenur YilmazDepartment of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey.
Nur Sena UzunayKoc University School of Medicine, Istanbul, Turkey.
Zeynep AktasDepartment of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey.
Muhammad Sohail HalimOcular Imaging Research and Reading Centre, Sunnyvale, CA, USA.
Yasir J SepahOcular Imaging Research and Reading Centre, Sunnyvale, CA, USA.
Quan Dong NguyenSpencer Centre for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Afsun SahinDepartment of Ophthalmology, Koç University School of Medicine, Istanbul, Turkey.
Koç University · TRGazi University · TROcular Surface Center · USSmith-Kettlewell Eye Research Institute · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

backgroundTo evaluate effect of maximal anterior cortical lens density, iris scatter and anterior chamber depth on laser flare photometry.

methodsPatients diagnosed with clinical uveitis were enrolled in the study. Clinical flare gradings were recorded upon the Standardization of Uveitis Nomenclature. Aqueous flare was measured with an automated device (Kowa FM-700). Back-scattering from anterior cortical lens and anterior iris surface was calculated from Scheimpflug images. A curvilinear regression model was used to calculate estimated values for each clinical grade. These values were used to split cases in Group I (laser flare photometry lower than estimated) and Group II (laser flare photometry higher than estimated). Mean anterior chamber depth, pupil aperture, maximal anterior cortical lens density and iris scatter values were compared between two groups. A stepwise multiple regression analysis was performed to determine the effect of clinical flare gradings and ocular parameters on aqueous flare measurements.

resultsThe study included 228 eyes of 114 cases. Scheimpflug images were obtained from 105 eyes. Estimated aqueous flare measurements (in photons/milliseconds) were 4.87, 8.50, 14.81, 25.83, 45.04 and 136.93 for 0, 0.5+, 1+, 1.5+, 2+ and 3+ clinical flare respectively. Group II had higher maximal anterior cortical lens density than Group I (96.6 ± 37.1 vs 77.9 ± 17.1 pixel unit,

conclusionThe back-scattered light from anterior cortical lens could affect laser flare photometry measurements. This effect might be quantified by Scheimpflug imaging.

Indexed as

UveitisUveitis, AnteriorAnterior ChamberAqueous HumorHumansLasersPhotometryAnterior chamberaqueous flarelaser flare photometerlensuveitis

Identifiers

PMID34382443
PMCPMC10919547
OpenAlexW3189053651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.