Evidence map›Paper›PMID 34382371›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Vitrification and Nanowarming of Kidneys.

Anirudh Sharma, Joseph Sushil Rao, Zonghu Han, Lakshya Gangwar, Baterdene Namsrai, Zhe Gao, Hattie L Ring, Elliott Magnuson, Michael Etheridge, Brian Wowk and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anirudh SharmaDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Joseph Sushil RaoDepartment of Surgery, University of Minnesota, Minneapolis, MN, 55455, USA.
Zonghu HanDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Lakshya GangwarDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Baterdene NamsraiDepartment of Surgery, University of Minnesota, Minneapolis, MN, 55455, USA.
Zhe GaoDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Hattie L RingCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, USA.
Elliott MagnusonDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Michael EtheridgeDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Brian Wowk21st Century Medicine Inc, Fontana, CA, 92336, USA.
Gregory M Fahy21st Century Medicine Inc, Fontana, CA, 92336, USA.
Michael GarwoodCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID 0000-0003-1578-9166
Erik B FingerDepartment of Surgery, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID 0000-0003-3899-6985
John C BischofDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID 0000-0001-6726-7111

Funding

Organ banking for transplant—kidney cryopreservation by vitrification and novel nanowarming technologyR01DK117425 · NIDDK · UNIVERSITY OF MINNESOTA · PI JOHN C BISCHOF, Erik Brian Finger · 2018 to 2026
$4.9M
Breakthrough Tissue and Organ Preservation and Transplantation Using Scaled-Up Nanowarming TechnologyR01HL135046 · NHLBI · UNIVERSITY OF MINNESOTA · PI BISCHOF, JOHN C, FINGER, ERIK BRIAN · 2017 to 2020
$2.6M
National Institutes of Health, National Heart, Lung, and Blood Institute 5R01HL135046-04National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK117425-03National Science Foundation EEC 1941543NHLBI NIH HHS R01 HL135046NIDDK NIH HHS R01 DK117425
6 · The paper itself

Abstract

Vitrification can dramatically increase the storage of viable biomaterials in the cryogenic state for years. Unfortunately, vitrified systems ≥3 mL like large tissues and organs, cannot currently be rewarmed sufficiently rapidly or uniformly by convective approaches to avoid ice crystallization or cracking failures. A new volumetric rewarming technology entitled "nanowarming" addresses this problem by using radiofrequency excited iron oxide nanoparticles to rewarm vitrified systems rapidly and uniformly. Here, for the first time, successful recovery of a rat kidney from the vitrified state using nanowarming, is shown. First, kidneys are perfused via the renal artery with a cryoprotective cocktail (CPA) and silica-coated iron oxide nanoparticles (sIONPs). After cooling at -40 °C min

Indexed as

NanoparticlesVitrificationAnimalsCryopreservationFerric CompoundsKidneyMaleModels, AnimalRatsRats, Sprague-DawleyRewarmingX-Ray MicrotomographyFerric Compoundsferric oxidecryopreservationiron oxide nanoparticleskidneyperfusionradiofrequency warmingvitrification

Identifiers

PMID34382371
PMCPMC8498880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.