Evidence map›Paper›PMID 34382351›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Survival-Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah

Ludi Zhang, Jian-Yun Ge, Yun-Wen Zheng, Zhen Sun, Chenhua Wang, Zhaoliang Peng, Baihua Wu, Mei Fang, Kinji Furuya, Xiaolong Ma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Anti-inflammatory and anti-angiogenic effects ofJournal of medicine and life · 2024
    Article
  4. Construction and characterization of a humanizedActa pharmaceutica Sinica. B · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ludi ZhangState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Science, Shanghai, 200031, China.
Jian-Yun GeDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Yun-Wen ZhengDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.ORCID 0000-0001-9002-3190
Zhen SunSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Chenhua WangState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Science, Shanghai, 200031, China.
Zhaoliang PengShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Baihua WuState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Science, Shanghai, 200031, China.
Mei FangInstitute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
Kinji FuruyaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Xiaolong MaState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Science, Shanghai, 200031, China.
Yanjiao ShaoShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Nobuhiro OhkohchiDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Tatsuya OdaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Jianglin FanGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, School of Biotechnology and Heath Sciences, Wuyi University, Jiangmen, Guangdong, 529020, China.
Guoyu PanShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Dali LiShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Lijian HuiState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Science, Shanghai, 200031, China.

Funding

Chinese Academy of Sciences XDA16020201Japan Society for the Promotion of Science JP18H02866MEXT (Ministry of Education, Culture, Sports, Science & Technology in Japan) scholarshipNational Key Research and Development Project 2019YFA0110802National Key Research and Development Project 2020YFA0112503National Natural Science Foundation of China 31930030National Natural Science Foundation of China 32025023National Natural Science Foundation of China 32070797National Natural Science Foundation of China 81770621National Natural Science Foundation of China 82070638SA-SIBS Scholarship ProgramYouth Innovation Promotion Association CAS
6 · The paper itself

Abstract

Although liver-humanized animals are desirable tools for drug development and expansion of human hepatocytes in large quantities, their development is restricted to mice. In animals larger than mice, a precondition for efficient liver humanization remains preliminary because of different xeno-repopulation kinetics in livers of larger sizes. Since rats are ten times larger than mice and widely used in pharmacological studies, liver-humanized rats are more preferable. Here, Fah

Indexed as

AnimalsDisease Models, AnimalDNA-Binding ProteinsHepatocytesHumansHydrolasesInterleukin Receptor Common gamma SubunitLiverNuclear ProteinsRatsDNA-Binding ProteinsfumarylacetoacetaseHydrolasesIL2RG protein, humanInterleukin Receptor Common gamma SubunitNuclear ProteinsRAG2 protein, humanbioreactorhumanized liverliver xeno-repopulationpharmacological study

Identifiers

PMID34382351
PMCPMC8498896

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.