Evidence map›Paper›PMID 34382142›Full record

ArticlePharmaceutical research2021

Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies.

Shrenik Mehta, Heather Flores, Benjamin Walters, Alavattam Sreedhara

Abstract read
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shrenik Mehta *Pharmaceutical Development, Genentech, 1 DNA Way, South San Francisco, California, 94080, USA.
Heather Flores *Pharmaceutical Development, Genentech, 1 DNA Way, South San Francisco, California, 94080, USA.
Benjamin WaltersGenentech Research and Early Development, 1 DNA Way, South San Francisco, California, 94080, USA.
Alavattam SreedharaPharmaceutical Development, Genentech, 1 DNA Way, South San Francisco, California, 94080, USA. sreedhaa@gene.com.
Gene Therapy Laboratory · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the physical and chemical degradation of monoclonal antibodies in the presence of Zn

methodsA full length IgG1 monoclonal antibody (mAb1) was formulated with various amounts of Zn

resultsmAb1 of the IgG1 subclass undergoes aggregation in the presence of Zn

conclusionsA novel metal ion mediated isodesmic aggregation mechanism was found in IgG1 class of monoclonal antibodies. Histidine residues in the Fc region were determined to be the binding site and implicated in Zn

Indexed as

Protein AggregatesAntibodies, MonoclonalBinding Sites, AntibodyCopperImmunoglobulin GProtein MultimerizationViscosityZincAntibodies, MonoclonalCopperImmunoglobulin GProtein AggregatesZinchigh molecular weight speciesIgG1 monoclonal antibodiesisodesmic polymerizationZn2+ mediated aggregation

Identifiers

PMID34382142
OpenAlexW3192993065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.