Evidence map›Paper›PMID 34382100›Full record

SynthesisCalcified tissue international2022

The Effects of Exercise on Bone Mineral Density in Men: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Blair R Hamilton, Katherine A Staines, George A Kelley, Kristi S Kelley, Wendy M Kohrt, Yannis Pitsiladis, Fergus M Guppy

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Calcified tissue international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Review
  9. Nutrients · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Blair R HamiltonThe Gender Identity Clinic, Tavistock and Portman NHS Foundation Trust, London, UK.
Katherine A StainesCentre for Stress and Age-Related Disease, University of Brighton, Brighton, UK.
George A KelleyDepartment of Epidemiology and Biostatistics, School of Public Health, West Virginia University, Morgantown, WV, USA.
Kristi S KelleyDepartment of Epidemiology and Biostatistics, School of Public Health, West Virginia University, Morgantown, WV, USA.
Wendy M KohrtDepartment of Medicine, Education, and Clinical Center, University of Colorado Anschutz Medical Campus, and Eastern Colorado VA Geriatric, ResearchAurora, CO, USA.
Yannis PitsiladisSchool of Sport and Health Sciences, University of Brighton, Brighton, UK.
Fergus M GuppyCentre for Stress and Age-Related Disease, University of Brighton, Brighton, UK. f.guppy@brighton.ac.uk.ORCID 0000-0002-8526-9169
University of Brighton · GBWest Virginia University · USForo Italico University of Rome · ITThe Tavistock and Portman NHS Foundation Trust · GBUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this systematic review and meta-analysis was to provide an updated analysis, including the use of more robust methods, on the effects of exercise on bone mineral density in men. Randomised Control Trials of > 24 weeks and published in English up to 01/05/20 were retrieved from 3 electronic databases, cross-referencing, and expert review. The primary outcome measures were changes in FN, LS, and lower limb BMD Standardised effect sizes were calculated from each study and pooled using the inverse heterogeneity model. A statistically significant benefit of exercise was observed on FN BMD [g = 0.21 (0.03, 0.40), Z = 2.23 p = 0.03], with no observed statistically significant benefit of exercise on LS BMD [g = 0.10 (- 0.07, 0.26), Z = 1.15 p = 0.25]. This analysis provided additional evidence to recommend ground- and/or joint-reaction force exercises for improving or maintaining FN, but not LS BMD. Additional well-designed RCTs are unlikely to alter this evidence, although interventions that include activities that directly load the lumbar spine are needed to ensure this is not a potential method of improving LS BMD.

Indexed as

Bone DensityExerciseHumansLumbar VertebraeMaleRandomized Controlled Trials as Topic

Identifiers

PMID34382100
OpenAlexW3191444082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.