Evidence map›Paper›PMID 34382022›Full record

ArticleSTAR protocols2021

Protocol for detecting plastic changes in defined neuronal populations in neuropathic mice.

Zizhen Zhang, Gerald W Zamponi

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zizhen ZhangDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Gerald W ZamponiDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
University of Calgary · CA

Funding

CIHR
6 · The paper itself

Abstract

Characterization of synaptic plasticity changes via optogenetic manipulation between defined neuronal populations is important for mapping neural circuits involved in normal brain functions and disorders such as neuropathic pain. However, determining the strength of synaptic transmission based on optogenetic manipulation is challenging due to variability in opsin expression. This protocol describes the use of slice electrophysiology combined with optogenetics to examine synaptic transmission in genetically defined neuronal populations from neuropathic mice. We detail surgical procedures of spared nerve injury for inducing neuropathy. For complete details on the use and execution of this protocol, please refer to Huang et al. (2019) and Huang et al. (2021).

Indexed as

AnimalsElectrodiagnosisMiceNeuralgiaNeuronal PlasticityNeuronsOptogeneticsPatch-Clamp TechniquesPeripheral Nervous System DiseasesSynaptic TransmissionCell BiologyModel OrganismsNeuroscience

Identifiers

PMID34382022
PMCPMC8333107
OpenAlexW3184080378

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.