Evidence map›Paper›PMID 34381988›Full record

ArticleMetabolism open2021

Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise.

Vinutha B Shetty, Grant Smith, Nirubasini Paramalingam, Heather C Roby, Elizabeth A Davis, Timothy W Jones, Paul A Fournier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vinutha B ShettyDepartment of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia.
Grant SmithChildren's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., Australia.
Nirubasini ParamalingamDepartment of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia.
Heather C RobyChildren's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., Australia.
Elizabeth A DavisDepartment of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia.
Timothy W JonesDepartment of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia.
Paul A FournierDepartment of Exercise Science and Health, School of Human Sciences, The University of Western Australia, Perth, W.A., Australia.
The Kids Research Institute Australia · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the role that antidiuretic hormone (ADH) may play in the activation of glucose production during high intensity aerobic exercise. MATERIALS/

methodsThis study was part of larger study based on a repeated measures cross-over study design and involved ten adult participants who exercised in the morning at 80 %

resultsThe levels of plasma ADH were 1.8 ± 0.2 pmol/L (mean ± SEM) at rest and increased to 10.5 ± 2.1 pmol/L at the end of exercise (mean ± SEM), which lasted 8.5-40 min. In response to exercise, glucose Ra also rose significantly (p < 0.05), but there was no significant association between changes in ADH levels and glucose Ra (r = 0.49; p = 0.150).

conclusionsAlthough the significant increase in glucose Ra and ADH levels during high intensity aerobic exercise suggest for the first time that these processes may be causally related, there was no significant association between these variables, maybe because of the small sample size and varying exercise durations. Hence, the importance of the causal role that ADH may play in the exercise-mediated activation of hepatic glucose production warrants further in depth investigations.

Indexed as

ADHADH, Antidiuretic hormoneAntidiuretic hormoneArginine vasopressinAVPBGL, Blood glucose levelsBlood glucose levelGlucose productionHigh intensity exerciseRa, Rate of glucose appearanceSE, Standard errorT1D, Type 1 diabetesType 1 diabetesVasopressinV̇O2peak, Peak rate of oxygen consumption

Identifiers

PMID34381988
PMCPMC8333141
OpenAlexW3185554012

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.