Evidence map›Paper›PMID 34381972›Full record

ArticleiScience2021

High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.

Laura Bouchareychas, Phat Duong, Tuan Anh Phu, Eric Alsop, Bessie Meechoovet, Rebecca Reiman, Martin Ng, Ryo Yamamoto, Hiromitsu Nakauchi, Warren J Gasper and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Acta pharmaceutica Sinica. B · 2024
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Laura BouchareychasDepartment of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Phat DuongNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Tuan Anh PhuNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Eric AlsopNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Bessie MeechoovetNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Rebecca ReimanNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Martin NgNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Ryo YamamotoInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA 94305, USA.
Hiromitsu NakauchiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA 94305, USA.
Warren J GasperDepartment of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Kendall Van Keuren-JensenNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Robert L RaffaiDepartment of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Translational Genomics Research Institute · USNorthern California Institute for Research and Education · USSan Francisco VA Medical Center · USStanford University · USUniversity of California, San Francisco · US

Funding

Hyperglycemia and MicroRNA Dysregulation of Inflammation in AtherosclerosisR01HL133575 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI RAFFAI, ROBERT · 2016 to 2019
$1.5M
P.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using MicrofluidicUH3CA241703 · NCI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MATEESCU, BOGDAN, RAFFAI, ROBERT · 2021 to 2022
$1.4M
P.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using MicrofluidicUG3CA241703 · NCI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MATEESCU, BOGDAN, RAFFAI, ROBERT · 2019 to 2020
$774k
BLRD VA I01 BX003928BLRD VA IK6 BX005692NCI NIH HHS UG3 CA241703NCI NIH HHS UH3 CA241703NHLBI NIH HHS R01 HL133575
6 · The paper itself

Abstract

We investigated whether extracellular vesicles (EVs) produced under hyperglycemic conditions could communicate signaling to drive atherosclerosis. We did so by treating Apoe

Indexed as

Cell biologyEndocrine system physiology

Identifiers

PMID34381972
PMCPMC8333149
OpenAlexW3183073976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.