Evidence map›Paper›PMID 34381967›Full record

ArticleiScience2021

Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function.

Jian Tan, Duan Ni, Jibran Abdul Wali, Darren Anthony Cox, Gabriela Veronica Pinget, Jemma Taitz, Claire Immediato Daïen, Alistair Senior, Mark Norman Read, Stephen James Simpson and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
  3. High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Frontiers in immunology · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Jian TanCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Duan NiCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Jibran Abdul WaliCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Darren Anthony CoxCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Gabriela Veronica PingetCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Jemma TaitzCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Claire Immediato DaïenCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Alistair SeniorCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Mark Norman ReadCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Stephen James SimpsonCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Nicholas Jonathan Cole KingCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Laurence MaciaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
The University of Sydney · AUCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While diet modulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportions in spleen, mesenteric lymph node and Peyer's patches, and increased antigen-specific immunoglobulin G production after immunization. This was linked to increased B lymphopoiesis in the bone marrow. Glucose promoted early B lymphopoiesis and higher total B lymphocyte numbers than fructose. It drove B cell development through glycolysis and oxidative phosphorylation, independently of fatty acid oxidation

Indexed as

Biological sciencesCell biologyDevelopmental biologyImmunology

Identifiers

PMID34381967
PMCPMC8333167
OpenAlexW3177811177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.