Evidence map›Paper›PMID 34381840›Full record

ReviewERJ open research2021

Detection and diagnosis of large airway collapse: a systematic review.

Alexandros Mitropoulos, Woo-Jung Song, Fatma Almaghlouth, Samuel Kemp, Michael Polkey, James H Hull

Open access · goldAbstract readReview
In one paragraph

Review in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Exercise and large airway issues.Physiological reports · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Unexplained disabling and long-lasting cough: a case report.Journal of cardiothoracic surgery · 2024
    Article
  10. Clinical and prognostic relevance ofJournal of feline medicine and surgery · 2024
    Article
  11. Review
  12. Article
  13. Review
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  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Alexandros MitropoulosDept of Respiratory Medicine, Royal Brompton Hospital, London, UK.
Woo-Jung SongDept of Allergy and Clinical Immunology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
Fatma AlmaghlouthNational Heart and Lung Institute, Imperial College, London, UK.
Samuel KempDept of Respiratory Medicine, Royal Brompton Hospital, London, UK.ORCID https://orcid.org/0000-0002-6639-0166
Michael PolkeyDept of Respiratory Medicine, Royal Brompton Hospital, London, UK.
James H HullDept of Respiratory Medicine, Royal Brompton Hospital, London, UK.ORCID https://orcid.org/0000-0003-4697-1526
Royal Brompton Hospital · GBImperial College London · GBUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large airway collapse (LAC) is a frequently encountered clinical problem, caused by tracheobronchomalacia +/- excessive dynamic airway collapse, yet there are currently no universally accepted diagnostic criteria. We systematically reviewed studies reporting a diagnostic approach to LAC in healthy adults and patients, to compare diagnostic modalities and criteria used. Electronic databases were searched for relevant studies between 1989 and 2019. Studies that reported a diagnostic approach using computed tomography (CT), magnetic resonance imaging or flexible fibreoptic bronchoscopy were included. Random effects meta-analyses were performed to estimate the prevalence of LAC in healthy subjects and in patients with chronic obstructive airway diseases. We included 41 studies, describing 10 071 subjects (47% female) with a mean±sd age of 59±9 years. Most studies (n=35) reported CT findings, and only three studies reported bronchoscopic findings. The most reported diagnostic criterion was a ≥50% reduction in tracheal or main bronchi calibre at end-expiration on dynamic expiratory CT. Meta-analyses of relevant studies found that 17% (95% CI: 0-61%) of healthy subjects and 27% (95% CI: 11-46%) of patients with chronic airways disease were classified as having LAC, using this threshold. The most reported approach to diagnose LAC utilises CT diagnostics, and at a threshold used by most clinicians (

Identifiers

PMID34381840
PMCPMC8350125
OpenAlexW3175587621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.