ArticleFrontiers in oncology2021
Outcome of Elderly Patients With Surgically Treated Brain Metastases.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Frailty indices in patients undergoing surgical resection of brain metastases: a systematic review.Neurosurgical review · 2023Pooled it
- Prognostic Factors Impacting Surgical Resection Outcomes in Elderly Patients With Brain Metastasis.The Kaohsiung journal of medical sciences · 2026Article
- The mFI-11 frailty index as a predictor of surgical outcomes in elderly patients with brain metastases.Brain & spine · 2026Article
- Risk Factors for Airway Complications After Thyroplasty and Arytenoid Adduction.JAMA otolaryngology-- head & neck surgery · 2025Article
- Frailty diminishes functional outcome in patients with nonaneurysmal subarachnoid hemorrhage: a dual specialized neurovascular center analysis.Journal of neurology · 2025Article
- The Role of Repeated Surgical Resections for Recurrent Brain Metastases in Older Population.Medicina (Kaunas, Lithuania) · 2024Article
- Surgical excision and radiotherapy for brain metastasis from colorectal cancer: How frailty and comorbidity indices influence outcome.The Kaohsiung journal of medical sciences · 2024Article
- Effect of sarcopenia and frailty on outcomes among patients with brain metastases.Journal of neuro-oncology · 2024Article
- Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis.Journal of neuro-oncology · 2023Observational
- Narrative Review of Multidisciplinary Management of Central Nervous Involvement in Patients with HER2-Positive Metastatic Breast Cancer: Focus on Elderly Patients.Advances in therapy · 2023Review
- Surgical treatment of cerebellar metastases in elderly patients: A threshold that moves forward?World neurosurgery: X · 2023Article
- Survival in patients with surgically treated brain metastases: does infratentorial location matter?Neurosurgical review · 2023Article
- Brain metastases in the elderly - Impact of residual tumor volume on overall survival.Frontiers in oncology · 2023Article
- Article
- Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis.Frontiers in oncology · 2021Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectIn the light of an aging population and ongoing advances in cancer control, the optimal management in geriatric patients with brain metastases (BM) poses an increasing challenge, especially due to the scarce data available. We therefore analyzed our institutional data with regard to factors influencing overall survival (OS) in geriatric patients with BM.
methodsBetween 2013 and 2018, patients aged ≥ 65 years with surgically treated BM were included in this retrospective analysis. In search of preoperatively identifiable risk factors for poor OS, in addition to the underlying cancer, the preoperative frailty of patients was analyzed using the modified Frailty Index (mFI).
resultsA total of 180 geriatric patients with surgically treated BM were identified. Geriatric patients categorized as least-frail achieved a median OS of 18 months, whereas frailest patients achieved an OS of only 3 months (p<0.0001). Multivariable cox regression analysis detected "multiple intracranial metastases" (p=0.001), "infratentorial localization" (p=0.011), "preoperative CRP >5 mg/l" (p=0.01) and "frailest patients (mFI ≥ 0.27)" (p=0.002) as predictors for reduced OS in older patients undergoing surgical treatment for BM.
conclusionsIn this retrospective series, pre-operative frailty was associated with poor survival in elderly patients with BM requiring surgery. Our analyses warrant thorough counselling and support of affected elderly patients and their families.
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