ArticleSchizophrenia research. Cognition2021
Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis.
Article in Schizophrenia research. Cognition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Co-occurring psychotic and eating disorders in England: findings from the 2014 Adult Psychiatric Morbidity Survey.Journal of eating disorders · 2022Article
- Associations between symptom and neurocognitive dimensions in clinical high risk for psychosis.Schizophrenia research. Cognition · 2022Article
- The specificity of the auditory P300 responses and its association with clinical outcomes in youth with psychosis risk syndrome.International journal of clinical and health psychology : IJCHPArticle
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical High Risk (CHS) for psychosis is a state in which positive symptoms are predominant but do not reach a level of severity that fulfils the criteria for a psychotic episode. The aim of this study has been to investigate whether cognition in subjects with newly detected CHR affects the longitudinal development of positive symptoms.
methodsFifty-three CHR individuals fulfilling the criteria for attenuated positive syndrome in the Structural Interview for Prodromal Syndromes (SIPS) were included. At inclusion, all participants completed a neurocognitive battery consisting of tests measuring attention, verbal memory, verbal fluency, executive functions and general intelligence. Cognitive domain z-scores were defined by contrasting with observed scores of a group of matched healthy controls (n = 40). Associations between cognitive performance at inclusion and longitudinal measures of positive symptoms were assessed by using generalised linear models including non-linear effects of time. All regression models were adjusted for age and gender.
resultsOverall, SIPS positive symptoms declined over the time period, with a steeper decline during the first six months. Deficits in executive functions were assossiated witn a higher load of positive symptoms at baseline (p=0.006), but also to a faster improvement (p=0.030), wheras those with poor verbal fluency improved more slowly (p=0.018).
conclusionTo our knowledge, this is the first study that follows CHR subjects by means of frequent clinical interviews over a sustained period of time. The study provides evidence of an association between executive functions, including verbal fluency, with the evolvement of positive symptoms.
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