Evidence map›Paper›PMID 34381672›Full record

ArticleGlobal heart2021

Clinical Profiles and Outcomes of Heart Failure in Five African Countries: Results from INTER-CHF Study.

Kamilu M Karaye, Hisham Dokainish, Ahmed ElSayed, Charles Mondo, Albertino Damasceno, Karen Sliwa, Kumar Balasubramanian, Alex Grinvalds, Salim Yusuf, investigators of INTERnational Congestive Heart Failure (INTER-CHF) Study

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Global heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 7 countries.

Kamilu M KarayeDepartment of Medicine, Bayero University/Aminu Kano Teaching Hospital, Kano, NG.
Hisham DokainishPopulation Health Research Institute, McMaster University, Hamilton, CA.
Ahmed ElSayedAlazhari Health Research Center, Alzaeim Alazhari University/AlShaab Teaching Hospital, Khartoum, SD.
Charles MondoMulago National Referral Hospital, Kampala, UG.
Albertino DamascenoFaculty of Medicine, Eduardo Mondlane University, Maputo, MZ.
Karen SliwaHatter Institute for Cardiovascular Research in Africa & Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, ZA.
Kumar BalasubramanianPopulation Health Research Institute, McMaster University, Hamilton, CA.
Alex GrinvaldsPopulation Health Research Institute, McMaster University, Hamilton, CA.
Salim YusufPopulation Health Research Institute, McMaster University, Hamilton, CA.
investigators of INTERnational Congestive Heart Failure (INTER-CHF) Study
Population Health Research Institute · CAAlzaiem Alazhari University · SDAminu Kano Teaching Hospital · NGEduardo Mondlane University · MZMcMaster University · CAMulago Hospital · UGUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A wide knowledge gap exists on the clinical profiles and outcomes of heart failure (HF) in sub-Saharan Africa. Objectives: To determine the clinical profiles and outcomes of HF patients from five African countries. Methods: The INTERnational Congestive Heart Failure Study (INTER-CHF) is a prospective, multicenter cohort study. A total of 1,294 HF patients were consecutively recruited from Nigeria (383 patients), South Africa (169 patients), Sudan (501 patients), Uganda (151patients), and Mozambique (90 patients). HF was defined according to the Boston criteria for diagnosis. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) score. Results: Of the 1294 patients, 51.4% were recruited as out-patients, 53.7% had HF with reduced ejection fraction (EF), 30.1% had HF with mid-range EF and 16.2% had HF with preserved EF (16.2%). The commonest etiologies of HF were hypertensive heart disease (35%) and ischemic heart disease (20%). The mean MoCA score was highest in Uganda (24.3 ± 1.1) and lowest in Sudan (13.6 ± 0.3). Prescriptions for guideline-recommended HF therapies were poor; only 1.2% of South African patients received an Implantable Cardioverter Defibrillator, and none of the patients received Cardiac Resynchronised Therapy. The composite outcome of death or HF hospitalization at one year among the patients was highest in Sudan (59.7%) and lowest in Mozambique (21.1%). Six variables were associated with higher mortality risk, while digoxin use (adjusted hazard ratio [aHR]: 0.69; 95% confidence interval [CI]: 0.49-0.97; p = 0.034) and 10mmHg unit increase in systolic blood pressure (aHR 0.86; 95%CI 0.81-0.93; p < 0.001) were associated with lower risk for mortality. Conclusions: This is the largest HF study in Africa that included in- and out-patients from the West, East, North, Central and South African sub-regions. Clinically relevant differences, including cognitive functional impairment, were found between the involved countries.

Indexed as

Heart FailureHospitalizationCohort StudiesHumansProspective StudiesSouth AfricaStroke VolumeAfricaEtiologyHeart FailureHospitalizationINTER-CHFMortality

Identifiers

PMID34381672
PMCPMC8323533
OpenAlexW3191388431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.