ArticleFrontiers in plant science2021
Integrated Metabolomics and Transcriptome Analysis of Flavonoid Biosynthesis in Safflower (
Article in Frontiers in plant science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed.
- Content Differences of Active Ingredients in Different Flower Colors ofCurrent issues in molecular biology · 2026Article
- Integrated Metabolome and Transcriptome Analysis Reveals the Effect of Anthocyanins on Flower Color Variation inBiology · 2026Article
- Identification and expression of the Glycyrrhiza uralensis GABA shunt gene family under drought and salt stress with exogenous GABA.Scientific reports · 2026Article
- Comprehensive characterization of safflower cytochrome P450 family and the role of CtCYP41 in flavonoid biosynthesis and drought response.BMC plant biology · 2026Article
- Natural Dyes and Antioxidant Compounds from Safflower (Plants (Basel, Switzerland) · 2026Article
- Integrated metabolome and transcriptome analysis reveals the potential mechanism of anthocyanin biosynthesis inFrontiers in plant science · 2026Article
- Integrative analysis of the metabolome and transcriptome reveals the mechanism of flower color and antioxidant capacity in threeFrontiers in plant science · 2026Article
- Effects of drying processes on the chemical and physical properties of safflower: Towards a multidimensional quality evaluation model.PloS one · 2026Article
- Integrative metabolomic and transcriptomic analyses reveal flavonoid biosynthesis pathway in Eupatorium lindleyanum.Scientific reports · 2025Article
- Genome-Wide Screening for MYB Transcription Factors Involved in Flavonoid Glycoside Biosynthesis inGenes · 2025Article
- Identification and Functional Analysis of Two UGT84 Glycosyltransferases in Flavonoid Biosynthesis ofPlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025Article
- Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower.International journal of molecular sciences · 2025Review
- Genome-Wide Identification of the ARF Gene Family in Safflower (International journal of molecular sciences · 2025Article
- Genome-wide identification and functional analyses of the TCP gene family in Carthamus tinctorius L.Scientific reports · 2025Article
- Integrating physiological and anatomical insights to unveil the mechanism of coloration in Prunus sibirica.Scientific reports · 2025Article
- Article
- Integrated Genetic Diversity and Multi-Omics Analysis of Colour Formation in Safflower.International journal of molecular sciences · 2025Article
- Integrated Metabolomics and Transcriptome Analysis of Anthocyanin Biosynthetic Pathway inPlants (Basel, Switzerland) · 2025Article
- Detection of Safflower Adulteration in Saffron Using Ion Mobility Spectroscopy.Journal of analytical methods in chemistry · 2025Article
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9 authors.
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Abstract
Safflower is widely used in dying and in traditional medicine, and C-glucosylquinochalcones are the main metabolic species in the red color of safflower. Various safflower cultivars have flowers with different colors. However, the metabolic and transcriptional differences among safflower cultivars with different-colored flowers and the genes participating in C-glucosylquinochalcone biosynthesis are largely unknown. To provide insights on this issue, we performed integrated metabolomics and transcriptome analyses on the flavonoid biosynthesis of flowers of different colors in safflower (white-W, yellow-Y, light red-LR, and deep red-DR). The metabolic analysis showed that flavonoid metabolites showed great differences among the different colors of safflower. More flavonoid metabolic species were detected in Y and W, while C-glucosylquinochalcones were not detected in W. The content of C-glucosylquinochalcones increased with increasing color. Transcriptional analysis showed that most of the annotated flavonoid biosynthesis genes were significantly increased in W. The expression of genes related to flavonoid biosynthesis decreased with increasing color. We analyzed the candidate genes associated with C-glucosylquinochalcones, and an integration of the metabolic and transcriptional analyses indicated that the differential expression of the chalcone synthase (CHS) gene is one of the main reasons for the difference in flavonoid species and content among the different colors of safflower. Combined with the expression pattern analysis, these results indicated that HH_035319, HH_032689, and HH_018025 are likely involved in C-glucosylquinochalcones biosynthesis. In addition, we found that their expression showed greatly increased after the methyl jasmonate (MeJA) treatment. Therefore, HH_035319, HH_032689, and HH_018025 might participate in C-glucosylquinochalcone biosynthesis, which ultimately leads to the red color in safflower.
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