ArticleFrontiers in neurology2021
The Contribution of Decreased Muscle Size to Muscle Weakness in Children With Spastic Cerebral Palsy.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03863197 (Treatment Algorithms Based on Muscle and Tendon Morphology - Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment Algorithms Based on Muscle and Tendon Morphology - Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of progressive functional ankle exercises in spastic cerebral palsy, plantarflexors versus dorsiflexors: a randomized trial.Turkish journal of medical sciences · 2023Trial
- Article
- Observational
- Clinimetric evaluation of the 1-minute sit-to-stand test as a functional performance measure associated with quadriceps strength in children with spastic hemiplegic cerebral palsy.BMC pediatrics · 2026Article
- Macrophages, muscle stem cells, and repair; immunohistochemical characteristics in muscle growth impairments in children with cerebral palsy.American journal of physiology. Cell physiology · 2026Article
- Body composition references, sarcopenia cutoffs, and prevalence in youth using bioelectrical impedance analysis.International journal of obesity (2005) · 2026Article
- Quantifying structural properties of forearm flexor muscles in individuals with hemiparetic cerebral palsy using diffusion tensor imaging.Physiological reports · 2025Article
- Cerebral Palsy Link to Sensorimotor System, Cognition, Emotion and Nociplastic Pain.Children (Basel, Switzerland) · 2025Review
- Article
- Efficacy of a Soft Robotic Exoskeleton to Improve Lower Limb Motor Function in Children with Spastic Cerebral Palsy: A Single-Blinded Randomized Controlled Trial.Brain sciences · 2024Article
- Effect of the Dynamic Orthotic Garment on Postural Control, and Endurance in Children with Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2024Article
- Reliability of 3D freehand ultrasound to assess lower limb muscles in children with spastic cerebral palsy and typical development.Journal of anatomy · 2023Article
- Morphological Medial Gastrocnemius Muscle Growth in Ambulant Children with Spastic Cerebral Palsy: A Prospective Longitudinal Study.Journal of clinical medicine · 2023Article
- Skeletal Muscle Measurements in Pediatric Hematology and Oncology: Essential Components to a Comprehensive Assessment.Children (Basel, Switzerland) · 2023Review
- How mechanics of individual muscle-tendon units define knee and ankle joint function in health and cerebral palsy-a narrative review.Frontiers in bioengineering and biotechnology · 2023Review
- Intra- and inter-subject variability of femoral growth plate stresses in typically developing children and children with cerebral palsy.Frontiers in bioengineering and biotechnology · 2023Article
- Review
- Aberrant movement-related somatosensory cortical activity mediates the extent of the mobility impairments in persons with cerebral palsy.The Journal of physiology · 2022Article
- Instrumented strength assessment in typically developing children and children with a neural or neuromuscular disorder: A reliability, validity and responsiveness study.Frontiers in physiology · 2022Article
- Progressive resistance training for children with cerebral palsy: A randomized controlled trial evaluating the effects on muscle strength and morphology.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle weakness is a common clinical symptom in children with spastic cerebral palsy (SCP). It is caused by impaired neural ability and altered intrinsic capacity of the muscles. To define the contribution of decreased muscle size to muscle weakness, two cohorts were recruited in this cross-sectional investigation: 53 children with SCP [median age, 8.2 (IQR, 4.1) years, 19/34 uni/bilateral] and 31 children with a typical development (TD) [median age, 9.7 (IQR, 2.9) years]. Muscle volume (MV) and muscle belly length for m. rectus femoris, semitendinosus, gastrocnemius medialis, and tibialis anterior were defined from three-dimensional freehand ultrasound acquisitions. A fixed dynamometer was used to assess maximal voluntary isometric contractions for knee extension, knee flexion, plantar flexion, and dorsiflexion from which maximal joint torque (MJT) was calculated. Selective motor control (SMC) was assessed on a 5-point scale for the children with SCP. First, the anthropometrics, strength, and muscle size parameters were compared between the cohorts. Significant differences for all muscle size and strength parameters were found (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.