ArticleNature neuroscience2021
Irregular distribution of grid cell firing fields in rats exploring a 3D volumetric space.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid-Beta Pathology in Alzheimer's Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- A Two-Dimensional Grid-Cell Code for Three-Dimensional Navigation in Freely Flying Bats.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal place cells map terrain geometry independently of behavior.Science advances · 2026Article
- Head direction cells use a head-referenced dual-axis updating rule in 3D space.Communications biology · 2026Article
- The Map's Design: Evolution's Impact on Navigation and Spatial Cognition.Animals : an open access journal from MDPI · 2025Review
- Grid cells accurately track movement during path integration-based navigation despite switching reference frames.Nature neuroscience · 2025Article
- Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories.eLife · 2025Article
- Translational differentiation of vertically displaced surfaces by grid cells.Current biology : CB · 2025Article
- Unweaving the Cognitive Map: A Personal History.Hippocampus · 2025Review
- Article
- Maintaining and updating accurate internal representations of continuous variables with a handful of neurons.Nature neuroscience · 2024Article
- Interactions between neural representations of the social and spatial environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A spatial transformation-based CAN model for information integration within grid cell modules.Cognitive neurodynamics · 2024Article
- Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus.Annual review of neuroscience · 2024Review
- Modeling hippocampal spatial cells in rodents navigating in 3D environments.Scientific reports · 2024Article
- Unpacking the navigation toolbox: insights from comparative cognition.Proceedings. Biological sciences · 2024Review
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- A Navigation Path Search and Optimization Method for Mobile Robots Based on the Rat Brain's Cognitive Mechanism.Biomimetics (Basel, Switzerland) · 2023Article
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Abstract
We investigated how entorhinal grid cells encode volumetric space. On a horizontal surface, grid cells usually produce multiple, spatially focal, approximately circular firing fields that are evenly sized and spaced to form a regular, close-packed, hexagonal array. This spatial regularity has been suggested to underlie navigational computations. In three dimensions, theoretically the equivalent firing pattern would be a regular, hexagonal close packing of evenly sized spherical fields. In the present study, we report that, in rats foraging in a cubic lattice, grid cells maintained normal temporal firing characteristics and produced spatially stable firing fields. However, although most grid fields were ellipsoid, they were sparser, larger, more variably sized and irregularly arranged, even when only fields abutting the lower surface (equivalent to the floor) were considered. Thus, grid self-organization is shaped by the environment's structure and/or movement affordances, and grids may not need to be regular to support spatial computations.
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