Evidence map›Paper›PMID 34381214›Full record

ArticleNature2021

A metabolic function of the hippocampal sharp wave-ripple.

David Tingley, Kathryn McClain, Ekin Kaya, Jordan Carpenter, György Buzsáki

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 118 citations in OpenAlex.

  1. Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026
    Article
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  5. Review
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  8. Time, space, memory and brain-body rhythms.Nature reviews. Neuroscience · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

David TingleyNeuroscience Institute, New York University, New York, NY, USA. davidtingley2@gmail.com.
Kathryn McClainCenter for Neural Science, New York University, New York, NY, USA.
Ekin KayaNeuroscience Institute, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0001-9235-4954
Jordan CarpenterNeuroscience Institute, New York University, New York, NY, USA.
György BuzsákiNeuroscience Institute, New York University, New York, NY, USA. gyorgy.buzsaki@nyumc.org.ORCID http://orcid.org/0000-0002-3100-4800
Neurosciences Institute · USNew York University · USNYU Langone Health · US

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Adam Christopher Mar · 2018 to 2026
$36.4M
Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI SOLTESZ, IVAN · 2017 to 2021
$13.2M
Transformation of Neuronal Activity in the Entorhinal-hippocampal-neocortex PathR01MH122391 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BASU, JAYEETA, BUZSAKI, GYORGY · 2020 to 2024
$3.3M
Training a new generation of computational neuroscientists bridging neurobiology and cognitionT90DA043219 · NIDA · NEW YORK UNIVERSITY · PI MA, WEI JI, WANG, XIAO-JING · 2016 to 2020
$615k
NIDA NIH HHS T90 DA043219NIH HHS MH122391NIMH NIH HHS R01 MH122391NINDS NIH HHS U19 NS104590NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

The hippocampus has previously been implicated in both cognitive and endocrine functions

Indexed as

HomeostasisAnimalsDiabetes Mellitus, Type 2GlucoseHippocampusHypothalamusOptogeneticsPharmacogeneticsRatsRats, Long-EvansSeptal NucleiSleepTime FactorsGlucose

Identifiers

PMID34381214
PMCPMC9214835
OpenAlexW3191965276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.