Evidence map›Paper›PMID 34381213›Full record

ArticleNature2021

Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution.

Zhaoming Su, Kaiming Zhang, Kalli Kappel, Shanshan Li, Michael Z Palo, Grigore D Pintilie, Ramya Rangan, Bingnan Luo, Yuquan Wei, Rhiju Das and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 104 citations in OpenAlex.

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  12. Blind prediction of complex water and ion ensembles around RNA in CASP16.bioRxiv : the preprint server for biology · 2025
    Article
  13. Structural insights into higher-order natural RNA-only multimers.Nature structural & molecular biology · 2025
    Article
  14. Article
  15. Article
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  17. Article
  18. Article
  19. Molecular insights into de novo small-molecule recognition by an intron RNA structure.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Zhaoming Su *The State Key Laboratory of Biotherapy and Cancer Center, Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. zsu@scu.edu.cn.ORCID http://orcid.org/0000-0002-9279-1721
Kaiming Zhang *Department of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA, USA.
Kalli Kappel *Biophysics Program, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2129-199X
Shanshan LiDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7041-5960
Michael Z PaloBiophysics Program, Stanford University, Stanford, CA, USA.
Grigore D PintilieDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA, USA.
Ramya RanganBiophysics Program, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0960-0825
Bingnan LuoThe State Key Laboratory of Biotherapy and Cancer Center, Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yuquan WeiThe State Key Laboratory of Biotherapy and Cancer Center, Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Rhiju DasBiophysics Program, Stanford University, Stanford, CA, USA. rhiju@stanford.edu.ORCID http://orcid.org/0000-0001-7497-0972
Wah ChiuDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA, USA. wahc@stanford.edu.ORCID http://orcid.org/0000-0002-8910-3078
Stanford University · USClark University · USSichuan University · CNUniversity of Science and Technology of China · CN

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M
3 D ELECTRON MICROSCOPY OF MACROMOLECULES (5P41RR002250-27)P41GM103832 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2012 to 2019
$15.1M
Unified Data Resource for Large Complexes Determined by Cryo-Electron MicroscopyR01GM079429 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2007 to 2021
$11.6M
Next-generation computational/chemical methods for complex RNA structuresR35GM122579 · NIGMS · STANFORD UNIVERSITY · PI Rhiju Das · 2017 to 2026
$7.2M
Acquisition of a 300 kV Electron Microscope for Structural BiologyS10OD021600 · OD · STANFORD UNIVERSITY · PI CHIU, WAH · 2016 to 2016
$2.0M
Structural interrogation of the HIV-1 5′ leader RNA by multidimensional chemical mapping and cryoelectron microscopyR21AI145647 · NIAID · STANFORD UNIVERSITY · PI CHIU, WAH · 2019 to 2020
$430k
NIAID NIH HHS P01 AI120943NIAID NIH HHS R21 AI145647NIGMS NIH HHS P41 GM103832NIGMS NIH HHS R01 GM079429NIGMS NIH HHS R35 GM122579NIH HHS S10 OD021600
6 · The paper itself

Abstract

Single-particle cryogenic electron microscopy (cryo-EM) has become a standard technique for determining protein structures at atomic resolution

Indexed as

Cryoelectron MicroscopyNucleic Acid ConformationTetrahymena thermophilaApoenzymesHoloenzymesModels, MolecularRNA, CatalyticApoenzymesHoloenzymesRNA, Catalytic

Identifiers

PMID34381213
PMCPMC8405103
OpenAlexW3192972855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.