ArticleNature2021
Aged skeletal stem cells generate an inflammatory degenerative niche.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 1 pooled it
31.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
252 citing papers in PubMed, 1 synthesis or guideline pooled it, 339 citations in OpenAlex.
- Consequences of Aging on Bone.Aging and disease · 2023Pooled it
- Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies.Regenerative therapy · 2026Review
- A senescent metabolism-modulating hierarchical scaffold restores NADBioactive materials · 2026Article
- Article
- Atractylenolide III attenuates age-related vertebral bone loss by suppressing macrophage inflammation and osteoclastogenesis.Bone reports · 2026Article
- Single-Cell Mapping Identifies Aging-Associated Neutrophil Remodeling Across Multiple Organs.Aging cell · 2026Article
- High-Fat Diet-Induced Metabolic Stress Durably Reprograms the Liver Regenerative Compartment Toward a Senescence-Like State.Aging cell · 2026Article
- Age-Dependent Effects of Macrophage Derived Cathelicidin Antimicrobial Peptide on Bone Fracture Repair.bioRxiv : the preprint server for biology · 2026Article
- Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Decoding Skeletal Biology Through Transcriptomics: Insights from Bulk, Single-Cell, Spatial, and Multi-Omics Approaches.International journal of molecular sciences · 2026Review
- Bone Aging and Glycative Stress: Convergent and Divergent Mechanisms Driving Skeletal Deterioration.Cells · 2026Review
- Skeletal stem and progenitor cell niche organization, regulation and repair.Reviews in endocrine & metabolic disorders · 2026Review
- Bone aging: a paradigm of multiscale degeneration and targeted rejuvenation.Bone research · 2026Review
- Noncircadian BMAL1-YAP activity amplifies persistent inflammation in aged epidermis.Nature aging · 2026Article
- Injury-driven stromal exhaustion disrupts intrinsic regenerative capability.Nature communications · 2026Article
- A Review of Rejuvenation Strategies Targeting Mesenchymal Stem Cell Senescence and Their Impact on Bone Health and Regeneration.Current osteoporosis reports · 2026Review
- Youthfulness of marrow AdipoqBone research · 2026Article
- Regional diversity of cranial skeletal stem cells governs bone morphogenetic protein-2 mediated bone regeneration.Nature communications · 2026Article
- IL-34 Regulates Macrophage Polarization and Bone Defect Healing in Aged Mice.International journal of molecular sciences · 2026Article
- Mechanisms limiting the long-term anabolic effects of teriparatide (PTH 1-34) on bone.JBMR plus · 2026Review
192 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 6 institutions in 3 countries.
Thomas H Ambrosi *Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7149-041X
Owen Marecic *Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1540-7191
Adrian McArdle *Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Gunsagar S GulatiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2798-6220
Xinming TongDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Yuting WangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Holly M SteiningerInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Malachia Y HooverInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Lauren S KoepkeInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Matthew P MurphyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0885-4089
Jan SokolInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Eun Young SeoInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Ruth TevlinInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Michael LopezInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Rachel E BrewerInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Shamik MascharakDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Laura LuDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Oyinkansola AjanakuDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Stephanie D ConleyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jun SeitaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Maurizio MorriChan Zuckerberg BioHub, San Francisco, CA, USA.
Norma F NeffChan Zuckerberg BioHub, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7141-5420
Debashis SahooPediatrics, and Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2329-8228
Fan YangDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Michael T LongakerInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. longaker@stanford.edu.ORCID http://orcid.org/0000-0003-1430-8914
Charles K F ChanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. chazchan@stanford.edu.ORCID http://orcid.org/0000-0001-6570-7574
Stanford University · USChan Zuckerberg Biohub San Francisco · USCalifornia Institute for Regenerative Medicine · USInstitute for Stem Cell Biology and Regenerative Medicine · INRIKEN Center for Integrative Medical Sciences · JPUniversity of California San Diego · US
Funding
Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE026914 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAI, YANG, CHEN, YONG · 2017 to 2019
$12.0MInduced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2MMacrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9MSummer Student Research on the Application of Boolean AnalysisR01GM138385 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2020 to 2023
$2.0MGraduate Training in Stem Cell Biology and Regenerative MedicineT32GM119995 · NIGMS · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2017 to 2021
$2.0MOsteogenic Enrichment of Adipose Derived Stromal CellsR01DE021683 · NIDCR · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2012 to 2016
$2.0MIdentifying the human skeletal stem cell.R01DE027323 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2018 to 2022
$1.9MCellular and Mechanical Mechanisms Regulating Mandibular Distraction OsteogenesisR01DE026730 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2017 to 2021
$1.9MCellular and molecular analyses of hematopoietic stem cell [HSC] interactions with bone marrow niches to improve HSC engraftment for transplantation and tolerance inductionR01DK115600 · NIDDK · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2018 to 2021
$1.5MNetwork-Based Novel Therapeutics in Colorectal CancersUG3TR002968 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2019 to 2021
$946kPrecision therapeutics of inflammatory bowel disease guided by Boolean logicUG3TR003355 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2020 to 2022
$937kEnhanced Calvarial Regeneration Via RNAi-Mediated Suppression of BMP AntagonismR21DE019274 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2008 to 2009
$768kNCATS NIH HHS UG3 TR002968NCATS NIH HHS UG3 TR003355NCI NIH HHS R00 CA151673NHLBI NIH HHS U01 HL099776NIAID NIH HHS R01 AI155696NIA NIH HHS K99 AG049958NIA NIH HHS K99 AG066963NIA NIH HHS R00 AG049958NIA NIH HHS R00 AG066963NIDCR NIH HHS R01 DE021683NIDCR NIH HHS R01 DE026730NIDCR NIH HHS R01 DE027323NIDCR NIH HHS R21 DE019274NIDCR NIH HHS R21 DE024230NIDCR NIH HHS R56 DE025597NIDCR NIH HHS U24 DE026914NIDDK NIH HHS R01 DK115600NIGMS NIH HHS R01 GM138385NIGMS NIH HHS T32 GM119995NIH HHS 1K99 AG066963NIH HHS S10 1S10 OD02349701
Abstract
Loss of skeletal integrity during ageing and disease is associated with an imbalance in the opposing actions of osteoblasts and osteoclasts
Indexed as
Cellular SenescenceStem Cell NicheAgingAnimalsBone and BonesBone Morphogenetic Protein 2Bone RegenerationCell LineageFemaleFracture HealingHematopoiesisInflammationMacrophage Colony-Stimulating FactorMaleMiceMyeloid CellsBmp2 protein, mouseBone Morphogenetic Protein 2CSF1 protein, mouseMacrophage Colony-Stimulating Factor
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.