ArticleCommunications biology2021
In situ motions of individual inner-hair-cell stereocilia from stapes stimulation in adult mice.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 33 citations in OpenAlex.
- Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture.Science advances · 2025Article
- Evaluation of thin-slice finite-element models for 3D cochlear organ of Corti mechanics.Hearing research · 2025Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.Scientific reports · 2022Article
- Review
- Dimensions of a Living Cochlear Hair Bundle.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In vertebrate hearing organs, mechanical vibrations are converted to ionic currents through mechanoelectrical-transduction (MET) channels. Concerted stereocilia motion produces an ensemble MET current driving the hair-cell receptor potential. Mammalian cochleae are unique in that the tuning of sensory cells is determined by their mechanical environment and the mode of hair-bundle stimulation that their environment creates. However, little is known about the in situ intra-hair-bundle motions of stereocilia relative to one another, or to their environment. In this study, high-speed imaging allowed the stereocilium and cell-body motions of inner hair cells to be monitored in an ex vivo organ of Corti (OoC) mouse preparation. We have found that the OoC rotates about the base of the inner pillar cell, the hair bundle rotates about its base and lags behind the motion of the apical surface of the cell, and the individual stereocilia move semi-independently within a given hair bundle.
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Registered trials
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