ArticleScientific reports2021
Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Prognostic Impact of Tumor Size in Patients with Stage T3N1 Colon Cancer.Journal of clinical medicine · 2025Article
- Tumor size in the management of preoperative radiotherapy for locally advanced rectal cancer.Discover oncology · 2025Article
- Delta Radiomics and Tumor Size: A New Predictive Radiomics Model for Chemotherapy Response in Liver Metastases from Breast and Colorectal Cancer.Tomography (Ann Arbor, Mich.) · 2025Article
- Lung adenocarcinoma size as a predictor of distant metastasis: A CT scan-based measurement.Narra J · 2024Article
- New findings in prognostic factor assessment for adenocarcinoma of transverse colon: a comparison study between competing-risk and COX regression analysis.Frontiers in medicine · 2024Article
- A predictive model for early death in elderly colorectal cancer patients: a population-based study.Frontiers in oncology · 2023Article
- Nomogram for predicting occurrence and prognosis of liver metastasis in elderly colorectal cancer patients: a population-based study.Frontiers in oncology · 2023Article
- Current Perspectives on the Importance of Pathological Features in Prognostication and Guidance of Adjuvant Chemotherapy in Colon Cancer.Current oncology (Toronto, Ont.) · 2022Article
- A Prediction Model for Tumor Recurrence in Stage II-III Colorectal Cancer Patients: From a Machine Learning Model to Genomic Profiling.Biomedicines · 2022Article
- A New Nomogram for Predicting the Postoperative Overall Survival in Patients with Middle-Aged and Elderly Rectal Cancer: A Single Center Retrospective Study in Chinese Population.International journal of general medicine · 2022Article
- Pathological Features and Prognostication in Colorectal Cancer.Current oncology (Toronto, Ont.) · 2021Review
- Association of Clinicopathological Factors With MMP13 (rs2252070) Gene Polymorphism in Swedish Patients With Colorectal Cancer.In vivo (Athens, Greece)Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the potential impact of tumor size on the long-term outcome of colon cancer (CC) patients after curative surgery. A total of 782 curatively resected T4a stage CC patients without distant metastasis were enrolled. Patients were categorized into 2 groups according to the best threshold of tumor size: larger group (LG) and smaller group (SG). Propensity score matching was used to adjust for the differences in baseline characteristics. The ideal cutoff point of tumor size was 5 cm. In the multivariate analysis for the whole study series, tumor size was an independent prognostic factor. Patients in the LG had significant lower 5-year overall survival (OS) and relapse-free survival (RFS) rates (OS: 63.5% versus 75.2%, P < 0.001; RFS: 59.5% versus 72.4%, P < 0.001) than those in the SG. After matching, patients in the LG still demonstrated significant lower 5-year OS and RFS rates than those in the SG. The modified tumor-size-node-metastasis (mTSNM) staging system including tumor size was found to be more appropriate for predicting the OS and RFS of T4a stage CC than TNM stage, and the -2log likelihood of the mTSNM staging system was smaller than the value of TNM stage. In conclusion, tumor size was an independent prognostic factor for OS and RFS. We maintain that tumor size should be incorporated into the staging system to enhance the accuracy of the prognostic prediction of T4a stage CC patients.
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