Evidence map›Paper›PMID 34381107›Full record

ArticleScientific reports2021

Decidualized endometrial stromal cells present with altered androgen response in PCOS.

Masuma Khatun, Alvin Meltsov, Darja Lavogina, Marina Loid, Keiu Kask, Riikka K Arffman, Henna-Riikka Rossi, Freddy Lättekivi, Kersti Jääger, Kaarel Krjutškov and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
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  9. The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation.Acta obstetricia et gynecologica Scandinavica · 2025 · on this map
    Review
  10. Review
  11. Article
  12. Polycystic ovary syndrome.Nature reviews. Disease primers · 2024
    Review
  13. Article
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  15. Article
  16. Article
  17. Article
  18. Androgen signalling in the ovaries and endometrium.Molecular human reproduction · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Masuma KhatunDepartment of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Alvin MeltsovCompetence Centre on Health Technologies, Tartu, Estonia.
Darja LavoginaCompetence Centre on Health Technologies, Tartu, Estonia.
Marina LoidCompetence Centre on Health Technologies, Tartu, Estonia.
Keiu KaskCompetence Centre on Health Technologies, Tartu, Estonia.
Riikka K ArffmanDepartment of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Henna-Riikka RossiDepartment of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Freddy LättekiviDepartment of Pathophysiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Kersti JäägerCompetence Centre on Health Technologies, Tartu, Estonia.
Kaarel KrjutškovCompetence Centre on Health Technologies, Tartu, Estonia.
Ago RinkenInstitute of Chemistry, University of Tartu, Tartu, Estonia.
Andres SalumetsCompetence Centre on Health Technologies, Tartu, Estonia.
Terhi T PiltonenDepartment of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland. terhi.piltonen@oulu.fi.
Competence Centre on Health Technologies (Estonia) · EEUniversity of Tartu · EEOulu University Hospital · FIUniversity of Oulu · FIEstonian University of Life Sciences · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperandrogenic women with PCOS show disrupted decidualization (DE) and placentation. Dihydrotestosterone (DHT) is reported to enhance DE in non-PCOS endometrial stromal cells (eSC

Indexed as

AdultAndrogensDihydrotestosteroneEndometriumEstradiolFemaleHumansPolycystic Ovary SyndromePregnancyProgesteroneSignal TransductionStromal CellsAndrogensDihydrotestosteroneEstradiolProgesterone

Identifiers

PMID34381107
PMCPMC8357821
OpenAlexW3187912435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.