Evidence map›Paper›PMID 34381062›Full record

ArticleScientific reports2021

The switch of DNA states filtering the extrinsic noise in the system of frequency modulation.

Shih-Chiang Lo, Chao-Xuan You, Bo-Ren Chen, Ching-Chu Hsieh, Cheng-En Li, Che-Chi Shu

Abstract read
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In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shih-Chiang LoDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Chao-Xuan YouDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Bo-Ren ChenDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Ching-Chu HsiehDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Cheng-En LiDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
Che-Chi ShuDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan. cshu@ntut.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon.

Indexed as

Computer SimulationDNAEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialOperonTranscription FactorsTranscription, GeneticDNAEscherichia coli ProteinsTranscription Factors

Identifiers

PMID34381062
PMCPMC8357933

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