ArticleNature communications2021
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- From hyperinflammation to recovery: serum immune biomarkers predict severity and track rapid inflammatory resolution in MIS-C.Pediatric research · 2026Article
- A study of gene expression in the living human brain.Molecular psychiatry · 2026Article
- Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases.Disease models & mechanisms · 2025Article
- SARS-CoV-2 Infection in Children: Revisiting Host-Virus Interactions Through Post-Infection Immune Profiling.Pathogens (Basel, Switzerland) · 2025Article
- An Update on Multi-System Inflammatory Syndrome in Children.Current rheumatology reports · 2025Review
- Exploratory study of the effect of DHA supplementation on blood fatty acids and inflammatory markers in children with MIS-C.Frontiers in nutrition · 2025Article
- Mechanistic insights into COVID-19 mRNA vaccine-associated myocarditis: a bioinformatics analysis.American journal of translational research · 2025Article
- Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).The Journal of experimental medicine · 2024Article
- Article
- The complex landscape of immune dysregulation in multisystem inflammatory syndrome in children with COVID-19.Life medicine · 2024Review
- B cell phenotype and serum levels of interferons, BAFF, and APRIL in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C).Molecular and cellular pediatrics · 2023Article
- Multisystem inflammatory syndrome in children (MIS-C): Implications for long COVID.Inflammopharmacology · 2023Review
- Innate immune dysregulation in multisystem inflammatory syndrome in children (MIS-C).Scientific reports · 2023Article
- Ancestry-based differences in the immune phenotype are associated with lupus activity.JCI insight · 2023Article
- Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-C.Cell reports. Medicine · 2023Article
- Emerging Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome Associated With COVID-19 in Children.The Canadian journal of cardiology · 2023Review
- Clinical and immunological features in children with multisystem inflammatory syndrome associated with SARS-CoV-2.Acta bio-medica : Atenei Parmensis · 2023Article
- Severe COVID-19European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Immunology of Multisystem Inflammatory Syndrome after COVID-19 in Children: A Review of the Current Evidence.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
91 authors at 7 institutions in 4 countries.
Noam D Beckmann *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. noam.beckmann@mssm.edu.
Phillip H Comella *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Esther Cheng *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lauren Lepow *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aviva G BeckmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Scott R TylerDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7683-6686
Konstantinos MouskasDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicole W SimonsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gabriel E HoffmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0957-0224
Nancy J FrancoeurDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Diane Marie Del ValleTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6983-5362
Gurpawan KangDepartment of Medicine, Division of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anh DoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emily MoyaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lillian WilkinsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jessica Le BerichelTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christie ChangPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7651-7220
Robert MarvinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sharlene CalorossiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alona LanskyPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laura WalkerPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nancy YiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alex YuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jonathan ChungTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthew HartnettIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Melody EatonPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sandra HatemTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hajra JamalHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alara AkyatanDepartment of of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexandra TabachnikovaHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lora E LiharskaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Liam CotterDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Brian FennessyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Akhil VaidDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Guillermo BarturenDepartment of Medical Genomics, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government (GENYO), Granada, Spain.ORCID http://orcid.org/0000-0003-2103-1028
Hardik ShahDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ying-Chih WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shwetha Hara SridharDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Juan SotoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Swaroop BoseDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kent MadridDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ethan EllisDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Elyze MerzierDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Konstantinos VlachosDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nataly FishmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manying TinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Melissa SmithDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hui XiePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manishkumar PatelPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7949-5610
Kai NiePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kimberly ArguetaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jocelyn HarrisPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neha KarekarPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Craig BatchelorPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jose LacunzaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mahlet YishakPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kevin TuballesPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ieisha ScottPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Arvind KumarGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-2865-1732
Suraj JaladankiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0406-2973
Charuta AgashePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ryan ThompsonDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0450-8181
Evan ClarkDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bojan LosicDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lauren PetersDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai COVID-19 Biobank Team
Panagiotis RoussosDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4640-6239
Jun ZhuIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0834-8178
Wenhui WangIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew KasarskisIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6454-9076
Benjamin S GlicksbergDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4515-8090
Girish NadkarniMount Sinai COVID Informatics Center, New York, NY, USA.
Dusan BogunovicDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cordelia ElaihoDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sandeep GangadharanDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
George Ofori-AmanfoDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kasey Alesso-CarraDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kenan OnelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Karen M WilsonDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carmen ArgmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1110-8012
Supinda BunyavanichDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6108-439X
Marta E Alarcón-RiquelmeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7632-4154
Thomas U MarronTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adeeb RahmanTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seunghee Kim-SchulzeTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sacha GnjaticTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5643-9520
Bruce D GelbDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8527-5027
Miriam MeradTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4481-7827
Robert SebraDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eric E SchadtDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eric.schadt@mssm.edu.ORCID http://orcid.org/0000-0002-7892-8808
Alexander W CharneyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.ORCID http://orcid.org/0000-0001-8135-6858
Icahn School of Medicine at Mount Sinai · USMount Sinai Medical Center · USNew York Stem Cell Foundation · USChild Health and Development Institute · USGenomics England · GBHasso Plattner Institute · DEPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ES
Funding
Mechanistic CoreU19AI066738 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI WOOD, ROBERT A · 2005 to 2016
$43.6MHigh-Dimensional Immune Monitoring of NCI-Supported Immunotherapy TrialsU24CA224319 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sacha Gnjatic, Seunghee Kim-Schulze · 2017 to 2026
$21.5MFood Allergy Research Consortium and Statistical CenterU01AI066560 · NIAID · THE EMMES COMPANY, LLC · PI DAWSON, PETER RUSSELL, LINDBLAD, ROBERT · 2005 to 2016
$12.8MThreshold, Severity, and Immunotherapy of Peanut AllergyU19AI136053 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUNYAVANICH, SUPINDA, SICHERER, SCOTT H · 2018 to 2023
$9.1MGut Microbiome Dynamics in Peanut AllergyR01AI147028 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUNYAVANICH, SUPINDA · 2019 to 2022
$3.3MCharacterizing and predicting colitis in immune checkpoint blockade-treated cancer patientsU01DK124165 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLOMBEL, JEAN-FREDERIC, FAITH, JEREMIAH JAMES · 2020 to 2024
$2.9MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MIdentifying Genetic Drivers of the Immunosuppressive Tumor Microenvironment in Lung CancerK00CA223015 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOLLAOGLU, GURKAN · 2019 to 2022
$374kNCI NIH HHS K00 CA223015NCI NIH HHS U24 CA224319NIAID NIH HHS R01 AI147028NIAID NIH HHS U01 AI066560NIAID NIH HHS U19 AI066738NIAID NIH HHS U19 AI136053NIDDK NIH HHS U01 DK124165NIH HHS S10 OD026880
Abstract
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs in individuals under 21 years of age in the weeks following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although an autoimmune pathogenesis has been proposed, the genes, pathways and cell types causal to this new disease remain unknown. Here we perform RNA sequencing of blood from patients with MIS-C and controls to find disease-associated genes clustered in a co-expression module annotated to CD56
Indexed as
AdolescentCD56 AntigenCD57 AntigensCD8-Positive T-LymphocytesChildChild, PreschoolCOVID-19Down-RegulationFemaleHumansInfantInfant, NewbornKiller Cells, NaturalMaleMucocutaneous Lymph Node SyndromeSARS-CoV-2CD56 AntigenCD57 Antigens
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