Evidence map›Paper›PMID 34380667›Full record

Observational studyBMJ (Clinical research ed.)2021

Evaluation of an intervention targeted with predictive analytics to prevent readmissions in an integrated health system: observational study.

Ben J Marafino, Gabriel J Escobar, Michael T Baiocchi, Vincent X Liu, Colleen C Plimier, Alejandro Schuler

Registry-linked trialOpen access · hybridAbstract readComparative StudyObservational Study
In one paragraph

Observational study in BMJ (Clinical research ed.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05765903 (Readmission Risk Score), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05765903 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Readmission Risk Score (RecuR Score) Pilot at The University of Maryland Charles Regional Medical Center (UM CRMC)

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2024 to 2026Enrolled0ConditionsPatient Readmission, Pulmonary Disease, Chronic Obstructive, Heart Failure, Diabetes Mellitus Poor ControlArmsStandard of Care, Enhanced Care
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ben J MarafinoBiomedical Informatics Training Program, Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA, USA marafino@stanford.edu.ORCID 0000-0003-2385-7376
Gabriel J EscobarSystems Research Initiative, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Michael T BaiocchiDepartment of Epidemiology and Population Health, Department of Medicine, Stanford University, Stanford, CA, USA.
Vincent X LiuSystems Research Initiative, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Colleen C PlimierSystems Research Initiative, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Alejandro SchulerSystems Research Initiative, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Kaiser Permanente · USStanford Medicine · USStanford University · US

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Identifying pre-sepsis opportunities for early, targeted intervention - Equipment SupplementR35GM128672 · NIGMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI Vincent Liu · 2018 to 2026
$4.3M
NIGMS NIH HHS R35 GM128672NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

objectivesTo determine the associations between a care coordination intervention (the Transitions Program) targeted to patients after hospital discharge and 30 day readmission and mortality in a large, integrated healthcare system.

designObservational study.

setting21 hospitals operated by Kaiser Permanente Northern California.

participants1 539 285 eligible index hospital admissions corresponding to 739 040 unique patients from June 2010 to December 2018. 411 507 patients were discharged post-implementation of the Transitions Program; 80 424 (19.5%) of these patients were at medium or high predicted risk and were assigned to receive the intervention after discharge.

interventionPatients admitted to hospital were automatically assigned to be followed by the Transitions Program in the 30 days post-discharge if their predicted risk of 30 day readmission or mortality was greater than 25% on the basis of electronic health record data.

main outcome measuresNon-elective hospital readmissions and all cause mortality in the 30 days after hospital discharge.

resultsDifference-in-differences estimates indicated that the intervention was associated with significantly reduced odds of 30 day non-elective readmission (adjusted odds ratio 0.91, 95% confidence interval 0.89 to 0.93; absolute risk reduction 95% confidence interval -2.5%, -3.1% to -2.0%) but not with the odds of 30 day post-discharge mortality (1.00, 0.95 to 1.04). Based on the regression discontinuity estimate, the association with readmission was of similar magnitude (absolute risk reduction -2.7%, -3.2% to -2.2%) among patients at medium risk near the risk threshold used for enrollment. However, the regression discontinuity estimate of the association with post-discharge mortality (-0.7% -1.4% to -0.0%) was significant and suggested benefit in this subgroup of patients.

conclusionsIn an integrated health system, the implementation of a comprehensive readmissions prevention intervention was associated with a reduction in 30 day readmission rates. Moreover, there was no association with 30 day post-discharge mortality, except among medium risk patients, where some evidence for benefit was found. Altogether, the study provides evidence to suggest the effectiveness of readmission prevention interventions in community settings, but further research might be required to confirm the findings beyond this setting.

Indexed as

AftercareAgedCaliforniaDelivery of Health Care, IntegratedElectronic Health RecordsFemaleHospitalizationHumansMaleMiddle AgedMortalityOutcome Assessment, Health CarePatient DischargePatient ReadmissionPredictive Value of TestsProgram Evaluation

Identifiers

PMID34380667
PMCPMC8356037
OpenAlexW3191487287

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.