Evidence map›Paper›PMID 34380645›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.

Kyla D Omilusik, Marija S Nadjsombati, Tomomi M Yoshida, Laura A Shaw, John Goulding, Ananda W Goldrath

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Post-Translational Regulation of CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kyla D OmilusikDivision of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA agoldrath@ucsd.edu komilusik@ucsd.edu.ORCID 0000-0003-3675-048X
Marija S NadjsombatiDivision of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA.ORCID 0000-0001-6632-8381
Tomomi M YoshidaDivision of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA.ORCID 0000-0003-4529-720X
Laura A ShawDivision of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA.ORCID 0000-0001-6595-1673
John GouldingDivision of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA.
Ananda W GoldrathDivision of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA agoldrath@ucsd.edu komilusik@ucsd.edu.ORCID 0000-0002-5900-508X
University of California San Diego · US

Funding

High-throughput targeted mutagenesis of mouse stem cell linesU01HG004080 · NHGRI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DE JONG, PIETER J. · 2006 to 2010
$28.1M
Production of Targeted Null Mutations for 10,000 Genes in C57BL/6 ES CellsU01HG004085 · NHGRI · REGENERON PHARMACEUTICALS, INC. · PI VALENZUELA, DAVID MANUEL · 2006 to 2010
$25.3M
UCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9M
T cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1M
Regulation of T cell immunity to viral infectionR01AI072117 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2008 to 2022
$5.4M
T cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0M
Transcriptional regulation of immunological memoryF31AG043222 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAW, LAURA · 2013 to 2016
$135k
NCRR NIH HHS U42 RR024244NHGRI NIH HHS U01 HG004080NHGRI NIH HHS U01 HG004085NIAID NIH HHS R01 AI067545NIAID NIH HHS R01 AI072117NIAID NIH HHS R37 AI067545NIA NIH HHS F31 AG043222
6 · The paper itself

Abstract

T cells are essential mediators of immune responses against infectious diseases and provide long-lived protection from reinfection. The differentiation of naive to effector T cells and the subsequent differentiation and persistence of memory T cell populations in response to infection is a highly regulated process. E protein transcription factors and their inhibitors, Id proteins, are important regulators of both CD4

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCells, CulturedImmunity, CellularImmunizationImmunologic MemoryInhibitor of Differentiation Protein 2Inhibitor of Differentiation ProteinsMiceMice, Inbred C57BLMice, KnockoutProtein Processing, Post-TranslationalUbiquitin-Specific ProteasesIdb2 protein, mouseIdb3 protein, mouseInhibitor of Differentiation Protein 2Inhibitor of Differentiation ProteinsUbiquitin-Specific ProteasesUsp1 protein, mouse

Identifiers

PMID34380645
PMCPMC8387442
OpenAlexW3156680075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.