Evidence map›Paper›PMID 34380610›Full record

ArticleScience advances2021

Brain-wide neural dynamics of poststroke recovery induced by optogenetic stimulation.

Shahabeddin Vahdat, Arjun Vivek Pendharkar, Terrance Chiang, Sean Harvey, Haruto Uchino, Zhijuan Cao, Anika Kim, ManKin Choy, Hansen Chen, Hyun Joo Lee and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022
    Pooled it
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  7. Medullary and C3-C4 propriospinal pathways underlying mammalian forelimb movement control.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Shahabeddin VahdatDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0494-6974
Arjun Vivek PendharkarDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0551-1478
Terrance ChiangDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Sean HarveyDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2153-8235
Haruto UchinoDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6567-8136
Zhijuan CaoDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0507-4645
Anika KimDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6720-8250
ManKin ChoyDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Hansen ChenDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9506-6894
Hyun Joo LeeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9139-7060
Michelle Y ChengDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. gsteinberg@stanford.edu ljinhy@stanford.edu mycheng@stanford.edu.ORCID http://orcid.org/0000-0003-3241-5174
Jin Hyung LeeDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. gsteinberg@stanford.edu ljinhy@stanford.edu mycheng@stanford.edu.ORCID http://orcid.org/0000-0001-7540-1018
Gary K SteinbergDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. gsteinberg@stanford.edu ljinhy@stanford.edu mycheng@stanford.edu.ORCID http://orcid.org/0000-0001-6374-1058
Stanford Medicine · USStanford University · USUniversity of Florida · US

Funding

Optogenetic Approaches to Study Post-Stroke Recovery MechanismsR01NS093057 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2015 to 2025
$5.8M
NINDS NIH HHS R01 NS093057
6 · The paper itself

Abstract

Poststroke optogenetic stimulations can promote functional recovery. However, the circuit mechanisms underlying recovery remain unclear. Elucidating key neural circuits involved in recovery will be invaluable for translating neuromodulation strategies after stroke. Here, we used optogenetic functional magnetic resonance imaging to map brain-wide neural circuit dynamics after stroke in mice treated with and without optogenetic excitatory neuronal stimulations in the ipsilesional primary motor cortex (iM1). We identified key sensorimotor circuits affected by stroke. iM1 stimulation treatment restored activation of the ipsilesional corticothalamic and corticocortical circuits, and the extent of activation was correlated with functional recovery. Furthermore, stimulated mice exhibited higher expression of axonal growth-associated protein 43 in the ipsilesional thalamus and showed increased Synaptophysin

Identifiers

PMID34380610
PMCPMC8357234
OpenAlexW3191925394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.