Evidence map›Paper›PMID 34380579›Full record

ArticlePublic health nutrition2022

Evaluation of iodine nutritional status during pregnancy by estimated 24-h urinary iodine excretion: population variation range and individual accuracy.

Ye Bu, Yan Cai, Chunlei Ji, Chunyan Zhao, Chunyuan Tian, Bo Pang, Mengqi Shi, Xin Li, Ying Liu, Dianjun Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ye BuKey Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No.196, Baojian road, Harbin, Heilongjiang 150086, People's Republic of China.
Yan CaiThe Fourth Affiliated Hospital of Harbin Medical University, Department of Obstetrics and Gynecology, Harbin, Heilongjiang, People's Republic of China.
Chunlei JiThe Fourth Affiliated Hospital of Harbin Medical University, Department of Obstetrics and Gynecology, Harbin, Heilongjiang, People's Republic of China.ORCID 0000-0002-7425-0681
Chunyan ZhaoThe Fourth Affiliated Hospital of Harbin Medical University, Department of Obstetrics and Gynecology, Harbin, Heilongjiang, People's Republic of China.
Chunyuan TianKey Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No.196, Baojian road, Harbin, Heilongjiang 150086, People's Republic of China.
Bo PangThe Fourth Affiliated Hospital of Harbin Medical University, Department of Obstetrics and Gynecology, Harbin, Heilongjiang, People's Republic of China.
Mengqi ShiNantong Center for Disease Control and Prevention, Nantong, Jiangsu Province, People's Republic of China.
Xin LiKey Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No.196, Baojian road, Harbin, Heilongjiang 150086, People's Republic of China.
Ying LiuKey Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No.196, Baojian road, Harbin, Heilongjiang 150086, People's Republic of China.
Dianjun SunKey Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No.196, Baojian road, Harbin, Heilongjiang 150086, People's Republic of China.ORCID 0000-0003-1701-4305

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the accuracy of estimated 24-h urinary iodine excretion (24-h UIEest) in assessing iodine nutritional status.

designFasting venous blood, 24-h and spot urine samples were collected during the day. The urinary iodine concentration (UIC) and urinary creatinine concentration (UCrC) were measured, and the urinary iodine-to-creatinine ratio (UI/Cr), 24-h UIEest, and 24-h urinary iodine excretion (24-h UIE) were calculated. At the population level, correlation and consistency between UIC, UI/Cr, 24-h UIEest and 24-h UIE were assessed using correlation analysis and Bland-Altman plots. At the individual level, receiver operating characteristic (ROC) curves were used to analyse the accuracy of the above indicators for evaluating insufficient and excessive iodine intake. The reference interval of 24-h UIEest was established based on percentile values.

settingIndicator can accurately evaluate individual iodine nutrition during pregnancy remains controversial.

participantsPregnant women (n 788).

resultsUsing 24-h UIE as standard, the correlation coefficients of 24-h UIEest from different periods of the day ranged from 0·409 to 0·531, and the relative average differences ranged from 4·4 % to 10·9 %. For diagnosis of insufficient iodine intake, the area under the ROC curve of 24-h UIEest was 0·754, sensitivity and specificity were 79·6 % and 65·4 %, respectively. For diagnosis of excessive iodine intake, the area of 24-h UIEest was 0·771, sensitivity and specificity were 66·7 % and 82·0 %, respectively. The reference interval of 24-h UIEest was 58·43-597·65 μg.

conclusionsTwenty-four-hour UIEest can better indicate iodine nutritional status at a relatively large sample size in a given population of pregnant women. It can be used for early screening at the individual level to obtain more lead time for pregnant women.

Indexed as

IodineCreatinineFemaleHumansNutritional StatusPregnancyPregnant PeopleReference ValuesCreatinineIodineEpidemiology studyEstimated iodine excretionIndividual assessmentIodine nutritionPregnant womenUrinary creatinineUrinary iodine excretion

Identifiers

PMID34380579
PMCPMC8883787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.