ArticleMicrobiome2021
Bacterial colonization dynamics and antibiotic resistance gene dissemination in the hospital environment after first patient occupancy: a longitudinal metagenetic study.
Article in Microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Impact of selective digestive decontamination on the pangenome composition of ESBL-E. coli.The Journal of antimicrobial chemotherapy · 2026Article
- Environmental reservoirs of carbapenem-resistant organisms in the intensive care unit: a multicenter longitudinal study in two middle-income country hospitals.Antimicrobial resistance and infection control · 2026Article
- Contact-mediated bacterial transmission and infection risk dynamics in a newly opened hospital ward.BMC microbiology · 2026Article
- Early detection of nosocomial pathogens in air and surfaces using an innovative genetic approach for surveillance in healthcare settings.Antimicrobial resistance and infection control · 2026Article
- Using electronic health records to assess the relationship between colonization pressure and nosocomial pathogen acquisition.Nature communications · 2026Article
- Prospective Whole-Genome Sequencing to Identify Bacterial Transmission and Its Modifiers in Neonates.JAMA network open · 2025Article
- The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens.npj antimicrobials and resistance · 2025Review
- Intrahospital dissemination of multidrug-resistantInfection prevention in practice · 2025Article
- Functional areas shape indoor microbial structure and potential risks in university dormitories.Frontiers in microbiology · 2025Article
- Addressing the global challenge of bacterial drug resistance: insights, strategies, and future directions.Frontiers in microbiology · 2025Review
- The indoors microbiome and human health.Nature reviews. Microbiology · 2024Review
- Department-specific patterns of bacterial communities and antibiotic resistance in hospital indoor environments.Applied microbiology and biotechnology · 2024Article
- Healthcare as a driver, reservoir and amplifier of antimicrobial resistance: opportunities for interventions.Nature reviews. Microbiology · 2024Review
- Aerosol-Mediated Spread of Antibiotic Resistance Genes: Biomonitoring Indoor and Outdoor Environments.International journal of environmental research and public health · 2024Review
- Biocontrol in built environments to reduce pathogen exposure and infection risk.The ISME journal · 2024Review
- Article
- Evaluation of pre-treated healthcare wastes during COVID-19 pandemic reveals pathogenic microbiota, antibiotics residues, and antibiotic resistance genes against beta-lactams.Environmental research · 2023Article
- New frontiers in healthcare environmental hygiene: thoughts from the 2022 healthcare cleaning forum.Antimicrobial resistance and infection control · 2023Article
- A novel therapeutic concern: Antibiotic resistance genes in common chronic diseases.Frontiers in microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHumans spend the bulk of their time in indoor environments. This space is shared with an indoor ecosystem of microorganisms, which are in continuous exchange with the human inhabitants. In the particular case of hospitals, the environmental microorganisms may influence patient recovery and outcome. An understanding of the bacterial community structure in the hospital environment is pivotal for the prevention of hospital-acquired infections and the dissemination of antibiotic resistance genes. In this study, we performed a longitudinal metagenetic approach in a newly opened ward at the Charité Hospital (Berlin) to characterize the dynamics of the bacterial colonization process in the hospital environment after first patient occupancy.
resultsThe sequencing data showed a site-specific taxonomic succession, which led to stable community structures after only a few weeks. This data was further supported by network analysis and beta-diversity metrics. Furthermore, the fast colonization process was characterized by a significant increase of the bacterial biomass and its alpha-diversity. The compositional dynamics could be linked to the exchange with the patient microbiota. Over a time course of 30 weeks, we did not detect a rise of pathogenic bacteria in the hospital environment, but a significant increase of antibiotic resistance determinants on the hospital floor.
conclusionsThe results presented in this study provide new insights into different aspects of the environmental microbiome in the clinical setting, and will help to adopt infection control strategies in hospitals and health care-related buildings. Video Abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.