Evidence map›Paper›PMID 34380547›Full record

ReviewMilitary Medical Research2021

Data mining in clinical big data: the frequently used databases, steps, and methodological models.

Wen-Tao Wu, Yuan-Jie Li, Ao-Zi Feng, Li Li, Tao Huang, An-Ding Xu, Jun Lyu

Open access · diamondAbstract readReview
In one paragraph

Review in Military Medical Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed, 4 pooled it
102.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

326 citing papers in PubMed, 4 syntheses or guidelines pooled it, 500 citations in OpenAlex.

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  16. DHX37 and tumor growth: a novel avenue for melanoma research.Journal of translational medicine · 2026
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  18. Applications of Artificial Intelligence (AI) in Breast Cancer Care Delivery and Education: A Scoping Review.International journal of environmental research and public health · 2026
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266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wen-Tao Wu *Department of Clinical Research, The First Affiliated Hospital of Jinan University, Tianhe District, 613 W. Huangpu Avenue, Guangzhou, 510632, Guangdong, China.
Yuan-Jie Li *Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
Ao-Zi FengDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Tianhe District, 613 W. Huangpu Avenue, Guangzhou, 510632, Guangdong, China.
Li LiDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Tianhe District, 613 W. Huangpu Avenue, Guangzhou, 510632, Guangdong, China.
Tao HuangDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Tianhe District, 613 W. Huangpu Avenue, Guangzhou, 510632, Guangdong, China.
An-Ding XuDepartment of Neurology, The First Affiliated Hospital of Jinan University, Tianhe District, 613 W. Huangpu Avenue, Guangzhou, 510632, Guangdong, China. tlil@jnu.edu.cn.
Jun LyuDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Tianhe District, 613 W. Huangpu Avenue, Guangzhou, 510632, Guangdong, China. lyujun2020@jnu.edu.cn.ORCID 0000-0002-2237-8771
First Affiliated Hospital of Jinan University · CNXi'an Jiaotong University · CN

Funding

National Social Science Foundation of China 16BGL183
6 · The paper itself

Abstract

Many high quality studies have emerged from public databases, such as Surveillance, Epidemiology, and End Results (SEER), National Health and Nutrition Examination Survey (NHANES), The Cancer Genome Atlas (TCGA), and Medical Information Mart for Intensive Care (MIMIC); however, these data are often characterized by a high degree of dimensional heterogeneity, timeliness, scarcity, irregularity, and other characteristics, resulting in the value of these data not being fully utilized. Data-mining technology has been a frontier field in medical research, as it demonstrates excellent performance in evaluating patient risks and assisting clinical decision-making in building disease-prediction models. Therefore, data mining has unique advantages in clinical big-data research, especially in large-scale medical public databases. This article introduced the main medical public database and described the steps, tasks, and models of data mining in simple language. Additionally, we described data-mining methods along with their practical applications. The goal of this work was to aid clinical researchers in gaining a clear and intuitive understanding of the application of data-mining technology on clinical big-data in order to promote the production of research results that are beneficial to doctors and patients.

Indexed as

Big DataDatabases, FactualData MiningHumansClinical big dataData miningMachine learningMedical public databaseMIMICNHANESSEERTCGA

Identifiers

PMID34380547
PMCPMC8356424
OpenAlexW3187536395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.