Evidence map›Paper›PMID 34380544›Full record

ArticleStem cell research & therapy2021

Human umbilical cord mesenchymal stem cells reduce oxidative damage and apoptosis in diabetic nephropathy by activating Nrf2.

Ping Nie, Xue Bai, Yan Lou, Yuexin Zhu, Shan Jiang, Lina Zhang, Na Tian, Ping Luo, Bing Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ping NieDepartment of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Xue BaiDepartment of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Yan LouDepartment of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Yuexin ZhuDepartment of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Shan JiangDepartment of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Lina ZhangResearch and Development Department, Jilin Tuohua Biotechnology Co., Ltd., Changchun, Jilin Province, China.
Na TianResearch and Development Department, Jilin Tuohua Biotechnology Co., Ltd., Changchun, Jilin Province, China.
Ping LuoDepartment of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, China. luopingjen@163.com.
Bing LiDepartment of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, China. li_bing2020@jlu.edu.cn.
Second Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) have a therapeutic effect on diabetic nephropathy (DN) but the underlying mechanism remains unclear. This study was conducted to investigate whether human umbilical cord-MSCs (hUCMSCs) can induce oxidative damage and apoptosis by activating Nrf2.

methodsWe used a type 2 diabetic rat model and a high-glucose and fat-stimulated human glomerular mesangial cell (hGMC) model. Western blotting, RT-qPCR, and TUNEL staining were performed on animal tissues and cultured cells. Nuclear expression of Nrf2 was detected in the renal tissue. Furthermore, Nrf2 siRNA was used to examine the effects of hUCMSCs on hGMCs. Finally, the effect of hUCMSCs on the Nrf2 upstream signalling pathway was investigated.

resultsAfter treatment with hUCMSCs, Nrf2 showed increased expression and nuclear translocation. After Nrf2-specific knockout in hGMCs, the protective effect of hUCMSCs on apoptosis induced by high-glucose and fat conditions was reduced. Activation of the PI3K signalling pathway may be helpful for ameliorating DN using hUCMSCs.

conclusionshUCMSCs attenuated renal oxidative damage and apoptosis in type 2 diabetes mellitus and Nrf2 activation is one of the important mechanisms of this effect. hUCMSCs show potential as drug targets for DN.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesMesenchymal Stem CellsAnimalsApoptosisHumansNF-E2-Related Factor 2Oxidative StressRatsUmbilical CordNF-E2-Related Factor 2ApoptosisDiabetic nephropathyMesenchymal stem cellNrf2Oxidative damage

Identifiers

PMID34380544
PMCPMC8356418
OpenAlexW3189074830

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.