ArticleBMC geriatrics2021
Association between handgrip strength and cognition in a Chinese population with Alzheimer's disease and mild cognitive impairment.
Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions.Journal of sport and health science · 2025Pooled it
- Use of handgrip strength measurement as an alternative for assessing chewing function in people with dementia.BMC geriatrics · 2022Trial
- A Pilot Study of Brain Metabolites and Their Diagnostic Cutoff Point in Postmenopausal Women With Cognitive Impairment Using Magnetic Resonance Spectroscopy.NMR in biomedicine · 2026Article
- Advancing Alzheimer's disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer's disease study (CPAS).Molecular psychiatry · 2026Review
- Association of Skeletal Muscle Strength with Cognitive Performance After Metabolic Bariatric Surgery.Journal of clinical medicine · 2026Article
- Handgrip strength across clinical conditions and health-related outcomes in older adults: a scoping review.Frontiers in aging · 2026Review
- Article
- Sarcopenia index is associated with Alzheimer's disease, mild cognitive impairment and their mortality in Chinese adults aged 65 and older.BMC public health · 2025Article
- Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology atRadiology · 2024Article
- The Effectiveness of an Exercise Program on Muscle Strength and Range of Motion on Upper Limbs, Functional Ability and Depression at Early Stage of Dementia.Journal of clinical medicine · 2024Article
- Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association of Serum Concentrations of Copper, Selenium, and Zinc with Grip Strength Based on NHANES 2013-2014.Biological trace element research · 2024Article
- White matter hyperintensities: a possible link between sarcopenia and cognitive impairment in patients with mild to moderate Alzheimer's disease.European geriatric medicine · 2023Article
- Objective Physical Function in the Alzheimer's Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study.International journal of molecular sciences · 2023Article
- The Relationship between Handgrip Strength, Timed Up-and-Go, and Mild Cognitive Impairment in Older People during COVID-19 Pandemic Restrictions.Behavioral sciences (Basel, Switzerland) · 2023Article
- Linguistic, visuospatial, and kinematic writing characteristics in cognitively impaired patients with beta-amyloid deposition.Frontiers in aging neuroscience · 2023Article
- Association of Muscle Strength with Non-Alcoholic Fatty Liver Disease in Korean Adults.International journal of environmental research and public health · 2022Article
- A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls.Healthcare (Basel, Switzerland) · 2022Article
- The Relationship Between Muscle Strength and Cognitive Performance Across Alzheimer's Disease Clinical Continuum.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThis study aimed to explore the level and changes in handgrip strength among preclinical Alzheimer's disease (AD) and AD patients and to evaluate the association between handgrip strength and cognitive function.
methodsA total of 1431 participants from the memory clinic of Shanghai JiaoTong University Affiliated Sixth People's Hospital and community were enrolled in the final analysis, including 596 AD, 288 mild cognitive impairment (MCI), and 547 normal individuals (NC). All participants received a comprehensive neuropsychological assessment. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment-Basic (MoCA-BC), and the Chinese version of Addenbrooke's Cognitive Examination III (ACE-III-CV) were used as cognitive tests. The receiver operating characteristic curve (ROC) was plotted to assess the power of handgrip strength as a screening measure to discriminate AD and MCI.
resultsThe results showed that handgrip strength in the MCI group was significantly lower than that of NC group, and the AD group had a further decline (both P < 0.01). Multivariate logistic regression was performed with the handgrip strength quartiles, and the results showed that the ORs of AD for increasing levels of handgrip strength were 1.00, 0.58 (0.46-0.78), 0.51 (0.36-0.73), and 0.50 (0.35-0.68), showing a decreasing trend (P
conclusionsOur study provided the further knowledge on the relationship between noncognitive features and cognition in populations with differing cognitive status, revealed that the stronger handgrip strength was associated with better performances on cognitive function. It can be speculated that handgrip strength can help early recognition of Chinese AD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.