Evidence map›Paper›PMID 34380418›Full record

ArticleBMC genomic data2021

Dissection of the impact of prioritized QTL-linked and -unlinked SNP markers on the accuracy of genomic selection

Ashley S Ling, El Hamidi Hay, Samuel E Aggrey, Romdhane Rekaya

Open access · goldAbstract read
In one paragraph

Article in BMC genomic data, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ashley S LingDepartment of Animal and Dairy Science, The University of Georgia, 30602, Athens, GA, USA. asling@uga.edu.ORCID 0000-0001-5923-3907
El Hamidi HayUSDA Agricultural Research Service, Fort Keogh Livestock and Range Research Laboratory, Miles City, MT, 59301, USA.
Samuel E AggreyDepartment of Poultry Science, The University of Georgia, 30602, Athens, GA, USA.
Romdhane RekayaDepartment of Animal and Dairy Science, The University of Georgia, 30602, Athens, GA, USA.
University of Georgia · USAgricultural Research Service · US

Funding

National Institute of Food and Agriculture 11754154
6 · The paper itself

Abstract

backgroundUse of genomic information has resulted in an undeniable improvement in prediction accuracies and an increase in genetic gain in animal and plant genetic selection programs in spite of oversimplified assumptions about the true biological processes. Even for complex traits, a large portion of markers do not segregate with or effectively track genomic regions contributing to trait variation; yet it is not clear how genomic prediction accuracies are impacted by such potentially nonrelevant markers. In this study, a simulation was carried out to evaluate genomic predictions in the presence of markers unlinked with trait-relevant QTL. Further, we compared the ability of the population statistic F

resultsWe found that the accuracy of genomic predictions decreased as the proportion of unlinked markers used to calculate the genomic relationships increased. Using all, only linked, and only unlinked marker sets yielded prediction accuracies of 0.62, 0.89, and 0.22, respectively. Furthermore, it was found that prediction accuracies are severely impacted by unlinked markers with large spurious associations. F

conclusionIdentification and exclusion of markers that have little to no relevance to the trait of interest may significantly increase genomic prediction accuracies. The population statistic F

Indexed as

Models, GeneticPolymorphism, Single NucleotideQuantitative Trait LociAnimalsGenetic MarkersGenomicsPlant BreedingGenetic MarkersAccuracyFST scoresGenomic predictionMarker preselection

Identifiers

PMID34380418
PMCPMC8356450
OpenAlexW3192822262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.