ArticlePsychiatry investigation2021
Aberrant Effective Connectivity of the Ventral Putamen in Boys With Attention-Deficit/Hyperactivity Disorder.
Article in Psychiatry investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Individualized prediction models in ADHD: a systematic review and meta-regression.Molecular psychiatry · 2024Pooled it
- Disrupted functional connectivity of the emotion regulation network in major depressive disorder and its association with symptom improvement: A multisite resting-state functional MRI study.Psychological medicine · 2025Article
- Altered gray matter volume and functional connectivity in adolescent borderline personality disorder with non-suicidal self-injury behavior.European child & adolescent psychiatry · 2024Article
- Specific brain imaging alterations underlying autistic traits in children with attention-deficit/hyperactivity disorder.Behavioral and brain functions : BBF · 2023Article
- Abnormal and Changing Information Interaction in Adults with Attention-Deficit/Hyperactivity Disorder Based on Network Motifs.Brain sciences · 2023Article
- Dynamic functional connectivity analysis with temporal convolutional network for attention deficit/hyperactivity disorder identification.Frontiers in neuroscience · 2023Article
- Structural differences among children, adolescents, and adults with attention-deficit/hyperactivity disorder and abnormal Granger causality of the right pallidum and whole-brain.Frontiers in human neuroscience · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
objectiveThe connectivity alterations in the putamen were found in revealing the neural correlates of attention-deficit/hyperactivity disorder (ADHD), but whether the effective connectivity of the putamen is atypical in ADHD remains unclear. Investigating this abnormality contributes to describing the neural circuit of ADHD at the level of macrostructural organization.
methodsData were acquired from thirty-two boys with ADHD and fifty-two matched typically developing controls (TDC) from Peking University (Peking) dataset deposited at the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) platform. We examined the effective connectivity of the putamen using Granger causality analysis (GCA) and then determined whether these connections could differentiate ADHD from TDC.
resultsCompared with TDC, the ADHD group showed decreased effective connectivity from the left ventral rostral putamen (VRP) to left calcarine (CAL), right medial part of the superior frontal gyrus, left orbital part of superior frontal gyrus and left middle occipital gyrus (MOG). Increased effective connectivity from the left inferior occipital gyrus and right lingual gyrus to left VRP was also found in ADHD. The result of the classification accuracy showed that 72.3% of participants were correctly classified using support vector machine. Moreover, GCA values from the left VRP to left CAL and left MOG were significantly correlated with hyper/impulsive scores of patients with ADHD.
conclusionThe findings may help extend our understanding of the ADHD-related neural loops.
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