ArticleDrug testing and analysis2022
A fast screening method for the detection of CERA in dried blood spots.
Article in Drug testing and analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- CERA Detection and Stability in Blood Versus Urine.Drug testing and analysis · 2026Article
- Volumetric Absorptive Microsampling in Toxicology.Toxics · 2024Review
- Detection of doping substances in paired dried blood spots and urine samples collected during doping controls in Danish fitness centers.Drug testing and analysis · 2024Article
- Use of RNA biomarkers in the antidoping field.Bioanalysis · 2024Review
- Blood microsampling technologies: Innovations and applications in 2022.Analytical science advances · 2023Review
- Detection of erythropoiesis stimulating agent Luspatercept after administration to healthy volunteers for antidoping purposes.Drug testing and analysis · 2022Article
- Optimizing detection of erythropoietin receptor agonists from dried blood spots for anti-doping application.Drug testing and analysis · 2022Article
- A fast screening method for the detection of CERA in dried blood spots.Drug testing and analysis · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous erythropoietin receptor activator (CERA) is a third-generation erythropoiesis-stimulating agent that was developed for the treatment of anemia. However, misuse of CERA for doping in endurance sports has been reported. Previous studies have shown blood as the matrix of choice for the detection of CERA, due to its high molecular weight. The use of dried blood spots (DBSs) for anti-doping purposes constitutes a complementary approach to the standard urine and venous blood matrices and could facilitate sample collection and increase the number of blood samples available for analysis due to reduced costs of sample collection and transport. Here, we investigated whether CERA could be indirectly detected in extracts of single DBSs using an erythropoietin-specific immunoassay that is capable of providing results within approximately 2 h. Reconstituted DBS samples were prepared from mixtures of red blood cell pellets and serum samples. The samples were collected in a previous clinical study in which six healthy volunteers were injected with a single, 200 μg dose of CERA. Using a commercially available ELISA kit, CERA was detected in the DBSs with a detection window of up to 20 days post-injection. Furthermore, in order to demonstrate the fitness-for-purpose, three authentic doping control serum samples, which were identified as containing CERA, were analyzed by the presented methodological approach on DBS. The testing procedure described here could be used as a fast and cost-effective method for the detection of CERA abuse in sport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.