ArticleCell reports2021
CXCL10
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- A novel CAF population coordinates hyper-suppressive regulatory T cell recruitment and localization in lung cancer.Nature immunology · 2026Article
- B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CD4Science (New York, N.Y.) · 2026Article
- The vicious cycle from inflammation to pyroptosis: the core role of macrophage polarization imbalance in the pathogenesis of knee osteoarthritis.Molecular biology reports · 2026Review
- Type 1-polarized DC immunotherapeutic contains heterogeneous populations with IL-12p70 production restricted to a rare subset.bioRxiv : the preprint server for biology · 2026Article
- Intravital imaging of the formation and resolution of MHC class II-positive T-cell activation niches.Life science alliance · 2026Article
- Review
- CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Neonatal liver niches program T cell tolerance.bioRxiv : the preprint server for biology · 2026Article
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Dectin-1-targeted pH-responsive liposomal nanoplatform delivering Plantago Asiatica L. acidic polysaccharide for immunomodulation and immunosuppressive breast cancer microenvironment reprogramming.Journal of nanobiotechnology · 2025Article
- Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination.The Journal of experimental medicine · 2025Article
- CXCR6 promotes dermal CD8bioRxiv : the preprint server for biology · 2025Article
- Spatial Patterning Analysis of Cellular Ensembles (SPACE) finds complex spatial organization at the cell and tissue levels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Brain Endothelial Cell Caveolin-1/CXCL10 Axis Promotes T Cell Transcellular Migration Across the Blood-Brain Barrier.ASN neuro · 2025Article
- Advances and challenges in identifying precursors of memory CD4Frontiers in immunology · 2025Review
- Peripheral CaeNeuro · 2024Article
- Article
- Atypical chemokine receptors in the immune system.Nature reviews. Immunology · 2024Review
- Tertiary lymphoid structures in anticancer immunity.Nature reviews. Cancer · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Hen PrizantDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.
Nilesh PatilDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.
Seble NegatuDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.
Noor BalaDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA; Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.
Alexander McGurkDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA; Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.
Scott A LeddonDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA; Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.
Angela HughsonDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.
Tristan D McRaeDepartment of Neuroscience and Multiphoton and Analytical Imaging Center, University of Rochester Medical Center, Rochester, NY, USA.
Yu-Rong GaoDepartment of Neuroscience and Multiphoton and Analytical Imaging Center, University of Rochester Medical Center, Rochester, NY, USA.
Alexandra M LivingstoneDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.
Joanna R GroomWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Andrew D LusterCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Deborah J FowellDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA; Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA. Electronic address: djf273@cornell.edu.
University of Rochester Medical Center · USCornell University · USHarvard University · USWalter and Eliza Hall Institute of Medical Research · AU
Funding
Tissue regulation of T cell function - Reagents CoreP01AI102851 · NIAID · UNIVERSITY OF ROCHESTER · PI Iwijn De Vlaminck · 2014 to 2026
$26.0MPOLIOVIRUS REPLICONS FOR HIV/SIV VACCINESP01AI028147 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LETVIN, NORMAN L · 1998 to 2002
$5.1MResource in Education in Microbiology and ImmunologyR25GM064133 · NIGMS · UNIVERSITY OF ROCHESTER · PI LORD, EDITH M · 2002 to 2017
$4.2MRemodeling of Lymph Node-Derived Cytokine Responses at the Infected Tissue SiteR01AI072690 · NIAID · UNIVERSITY OF ROCHESTER · PI FOWELL, DEBORAH J · 2008 to 2020
$3.6MThe CXCR3 Chemokine System in Cancer ImmunotherapyR01CA204028 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LUSTER, ANDREW D · 2017 to 2021
$1.9MRemodeling of Lymph Node-Derived Cytokine Responses at the Infected Tissue SiteR37AI072690 · NIAID · CORNELL UNIVERSITY · PI Deborah J Fowell · 2023 to 2026
$1.9MTarget T Cell Modulation by CD4+CD25+ Regulatory T CellsR01AI070826 · NIAID · UNIVERSITY OF ROCHESTER · PI FOWELL, DEBORAH J · 2007 to 2010
$1.5MRole of focal CXCL10 in shaping Th1 micro-positioning and function in inflamed skinF32AI138415 · NIAID · UNIVERSITY OF ROCHESTER · PI PRIZANT, HEN · 2018 to 2020
$142kNCI NIH HHS R01 CA204028NIAID NIH HHS F32 AI138415NIAID NIH HHS P01 AI028147NIAID NIH HHS P01 AI102851NIAID NIH HHS R01 AI070826NIAID NIH HHS R01 AI072690NIAID NIH HHS R37 AI072690NIGMS NIH HHS R25 GM064133
Abstract
Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation. We reveal that tissue entry and initial peripheral activation of Th1 effector T cells are tightly linked to perivascular positioning of chemokine-expressing APCs. Dermal inflammation induces tissue-wide de novo generation of discrete perivascular CXCL10
Indexed as
AnimalsAntigen-Presenting CellsAntigensAntigens, CDCell AggregationChemokine CXCL10EarHistocompatibility Antigens Class IIHumansInflammationInterferon-gammaLymphocyte ActivationMiceMice, TransgenicReceptors, CXCR3SkinAntigensAntigens, CDChemokine CXCL10Histocompatibility Antigens Class IIInterferon-gammaReceptors, CXCR3CD4 T cellschemokineCXCL10CXCR3inflammationintra-vital multiphoton microscopymoDCsperivascularskinTh1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.