Evidence map›Paper›PMID 34380020›Full record

ReviewStem cell reports2021

EBiSC best practice: How to ensure optimal generation, qualification, and distribution of iPSC lines.

Rachel Steeg, Sabine C Mueller, Nancy Mah, Bjørn Holst, Alfredo Cabrera-Socorro, Glyn N Stacey, Paul A De Sousa, Aidan Courtney, Heiko Zimmermann

Abstract readReview
In one paragraph

Review in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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  8. Guidelines for Manufacturing and Application of Organoids: Skin.International journal of stem cells · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel SteegFraunhofer UK Research Ltd, Glasgow, UK.
Sabine C MuellerFraunhofer Institute for Biomedical Engineering (IBMT), Joseph-von-Fraunhofer-Weg 1, 66280 Sulzbach, Germany.
Nancy MahFraunhofer Institute for Biomedical Engineering (IBMT), Joseph-von-Fraunhofer-Weg 1, 66280 Sulzbach, Germany.
Bjørn HolstBioneer A/S, Kogle Alle 2, 2970 Hørsholm, Denmark.
Alfredo Cabrera-SocorroNeuroscience Department, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium.
Glyn N StaceyInternational Stem Cell Banking Initiative, 2 High Street, Barley, Herts SG88HZ, UK; National Stem Cell Resource Centre, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China; Innovation Academy for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Paul A De SousaPaul A. De Sousa, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Aidan CourtneyKWWK Ltd, Edinburgh, UK.
Heiko ZimmermannFraunhofer Institute for Biomedical Engineering (IBMT), Joseph-von-Fraunhofer-Weg 1, 66280 Sulzbach, Germany; Molecular and Cellular Biotechnology/Nanotechnology, Saarland University, 66123 Saarbrücken, Germany; Facultad de Ciencias del Mar, Universidad Católica del Norte, Coquimbo, Chile. Electronic address: heiko.zimmermann@ibmt.fraunhofer.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disease-relevant human induced pluripotent stem cells (iPSCs) are generated worldwide for research purposes; however, without robust and practical ethical, legal, and quality standards, there is a high risk that their true potential will not be realized. Best practices for tissue procurement, iPSC reprogramming, day-to-day cultivation, quality control, and data management aligned with an ethical and legal framework must be included into daily operations to ensure their promise is maximized. Here we discuss key learning experiences from 7 years of operating the European Bank for induced Pluripotent Stem Cells (EBiSC) and recommend how to incorporate solutions into a daily management framework.

Indexed as

Biological Specimen BanksCell Culture TechniquesCell DifferentiationCell LineCellular ReprogrammingCryopreservationEuropeHumansInduced Pluripotent Stem CellsQuality Controlbankingbiobankdata managementEBiSCethicsguidanceiPSClegalqualityquality controlrepositoryreprogramming

Identifiers

PMID34380020
PMCPMC8365092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.