ArticleSleep2022
Cortical thinning and sleep slow wave activity reductions mediate age-related improvements in cognition during mid-late adolescence.
Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- The Role of Sleep for Age-Related Differences in Neurobehavioral Performance.Life (Basel, Switzerland) · 2024Article
- Associations between Sleep, Depression, and Cognitive Performance in Adolescence.European journal of investigation in health, psychology and education · 2023Article
- Associations of psychological resilience with macro- and microstructures in NREM and REM sleep in adolescents.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesGains in cognitive test performance that occur during adolescence are associated with brain maturation. Cortical thinning and reduced sleep slow wave activity (SWA) are markers of such developmental changes. Here we investigate whether they mediate age-related improvements in cognition.
methods109 adolescents aged 15-19 years (49 males) underwent magnetic resonance imaging, polysomnography (PSG), and a battery of cognitive tasks within a 2-month time window. Cognitive tasks assessed nonverbal intelligence, sustained attention, speed of processing and working memory and executive function. To minimize the effect of sleep history on SWA and cognitive performance, PSG and test batteries were administered only after at least 8 nights of 9-h time-in-bed (TIB) sleep opportunity.
resultsAge-related improvements in speed of processing (r = 0.33, p = 0.001) and nonverbal intelligence (r = 0.24, p = 0.01) domains were observed. These cognitive changes were associated with reduced cortical thickness, particularly in bilateral temporoparietal regions (rs = -0.21 to -0.45, ps < 0.05), as well as SWA (r = -0.35, p < 0.001). Serial mediation models found that ROIs in the middle/superior temporal cortices, together with SWA mediated the age-related improvement observed on cognition.
conclusionsDuring adolescence, age-related improvements in cognition are mediated by reductions in cortical thickness and sleep SWA.
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