ArticleGlycobiology2022
Identification and characterization of O-linked glycans in cervical mucus as biomarkers of sperm transport: A novel sheep model.
Article in Glycobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas.eLife · 2026Article
- Exploratory analyses of cervicovaginal mucus O-glycan composition and microbiota profiles in unexplained infertility.Glycobiology · 2026Article
- Towards cervical AI of sheep with stored semen: latest insights and future developments.The Journal of reproduction and development · 2026Review
- Proteomic signatures of cervical mucus associated with fertility in Bali heifers (Veterinary world · 2026Article
- Atom-level machine learning of protein-glycan interactions and cross-chiral recognition in glycobiology.Science advances · 2025Article
- Sialidases derived frombioRxiv : the preprint server for biology · 2025Article
- The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Characterization of Ovine Cervical Mucus and Implementation of a Sperm-Mucus Penetration Test Using Fluorescently Labeled Sperm.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Reproductive Tract Mucus May Influence the Sex of Offspring in Cattle: Study in Cows That Have Repeatedly Calved Single-Sex Offspring.Veterinary sciences · 2024Article
- An Observation of the Microstructure of Cervical Mucus in Cows during the Proestrus, Estrus, and Metestrus Stages and the Impact on Sperm Penetration Ability.Veterinary sciences · 2024Article
- Article
- Metabolic signature of cervical mucus in ewe breeds with divergent cervical sperm transport: a focus on metabolites involved in amino acid metabolism.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Cervical immune activation during the luteal phase may compromise subsequent trans-cervical ram sperm transport†.Biology of reproduction · 2022Article
- Biochemical and molecular characterization of sialylated cervical mucins in sheep†.Biology of reproduction · 2022Article
- Conserved and breed-specific differences in the cervical transcriptome of sheep with divergent fertility at the follicular phase of a natural oestrus cycle.BMC genomics · 2021Article
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical mucus plays an important role in female fertility, since it allows the entry of motile and morphological normal sperm while preventing the ascent of pathogens from the vagina. The function of cervical mucus is critically linked to its rheological properties that are in turn dictated by O-glycosylated proteins, called mucins. We aimed to characterize the O-glycan composition in the cervical mucus of six European ewe breeds with known differences in pregnancy rates following cervical/vaginal artificial insemination with frozen-thawed semen, which are due to reported differences in cervical sperm transport. These were Suffolk (low fertility) and Belclare (medium fertility) in Ireland, Ile de France and Romanov (both with medium fertility) in France, and Norwegian White Sheep (NWS) and Fur (both with high fertility) in Norway (n = 28-30 ewes/breed). We identified 124 O-glycans, from which 51 were the major glycans with core 2 and fucosylated glycans as the most common structures. The use of exogenous hormones for synchronization did not affect the O-glycan composition in both high-fertility ewe breeds, but it did in the other four ewe breeds. There was a higher abundance of the sulfated glycan (Galβ1-3[SO3-GlcNAcβ1-6]GalNAc), fucosylated glycan (GlcNAcβ1-3(Fucα1-2Galβ1-3)GalNAc) and core 4 glycan (GlcNAcβ1-3[GlcNAcβ1-6]GalNAc) in the low-fertility Suffolk breed compared with NWS (high fertility). In addition, core 4 glycans were negatively correlated with mucus viscosity. This novel study has identified O-glycans that are important for cervical sperm transport and could have applications across a range of species including human.
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