ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Olfaction and Physical Functioning in Older Adults: A Longitudinal Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06600438 (Slow-SPEED-United Kingdom), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Slow-SPEED-United Kingdom: A Double-Blind Randomised Feasibility Trial of a Remote Gamified Physical Activity Programme in Adults With Hyposmia.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of olfactory function with brain structural and functional outcomes. A systematic review.Ageing research reviews · 2023Pooled it
- Olfaction and muscle strength in older adults: a longitudinal study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.JAMA otolaryngology-- head & neck surgery · 2026Article
- Plasma lipids connecting olfaction with cognition and physical function.Scientific reports · 2026Article
- Article
- Olfaction and Coronary Heart Disease.JAMA otolaryngology-- head & neck surgery · 2026Article
- Poor olfaction and risk of heart failure in the Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- The scent of mating strategy: sociosexual orientation was associated with olfaction and body odor sniffing behavior in Chinese and American populations.BMC psychology · 2025Article
- Longitudinal Association of Olfactory Function with Frailty in Older Adults: The Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Better olfaction was associated with lower healthcare expenditure among physically independent Japanese community-dwelling older adults: the Yanai study.Frontiers in aging · 2025Article
- Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults.Journal of the American Heart Association · 2024Article
- Normative Data for the 12-Item Sniffin' Sticks Odor Identification Test in Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Presymptomatic Profiles of Cognitive Impairment with Prior Mobility Impairment.Journal of the American Medical Directors Association · 2024Article
- Use of nonsteroidal anti-inflammatory drugs and poor olfaction in women.International forum of allergy & rhinology · 2024Article
- Olfaction and Mobility in Older Adults.JAMA otolaryngology-- head & neck surgery · 2024Article
- An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
- Factors Associated with Poor Olfaction and Olfactory Decline in Older Adults in the ARIC Neurocognitive Study.Nutrients · 2023Article
- Ambient Air Pollutants and Olfaction among Women 50-79 Years of Age from the Sister Study.Environmental health perspectives · 2023Article
- The Implications of Taste and Olfaction in Nutrition and Health.Nutrients · 2023Article
- Associations of Olfaction With Longitudinal Trajectories of Brain Volumes and Neuropsychological Function in Older Adults.Neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPoor olfaction is associated with worse functional performance in older adults, but longitudinal evidence is lacking. We investigated poor olfaction in relation to longitudinal changes in physical functioning among community-dwelling older adults.
methodThe analysis included 2 319 participants from the Health, Aging and Body Composition study (aged 71-82 years, 47.9% men, and 37.3% Blacks) who completed the Brief Smell Identification Test in 1999-2000. Olfaction was defined as good (test score 11-12), moderate (9-10), or poor (0-8). Physical functioning was assessed up to 4 times over 8 years, using the Short Physical Performance Battery (SPPB) and the Health Aging and Body Composition Physical Performance Battery (HABCPPB). We conducted joint model analyses and reported the differences in annual declines across olfaction groups.
resultsDuring the follow-up, compared to those with good olfaction, older adults with poor olfaction had greater annual declines in both the SPPB score (-0.137, 95% CI: -0.186, -0.088) and all its subscales: standing balance (-0.068, 95% CI: -0.091, -0.044), chair stand (-0.046, 95% CI: -0.070, -0.022), and gait speed (-0.022, 95% CI: -0.042, -0.001). A similar observation was made for the HABCPPB score (difference in annual decline: -0.032, 95% CI: -0.042, -0.021). These findings are robust and cannot be explained by measured confounding from demographics, lifestyle factors, and chronic diseases or by potential biases due to death and loss of follow-up. Similar associations were observed across subgroups of sex, race, and self-reported general health status.
conclusionThis study provides the first epidemiological evidence that poor olfaction predicts a faster decline in physical functioning. Future studies should investigate potential mechanisms.
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